ArticleNucleic acids research2009
Strand selective generation of endo-siRNAs from the Na/phosphate transporter gene Slc34a1 in murine tissues.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Interdependent Transcription of a Natural Sense/Antisense Transcripts Pair (Non-coding RNA · 2022Article
- Natural antisense transcripts drive a regulatory cascade controlling c-MYC transcription.RNA biology · 2017Article
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- Natural Antisense Transcripts at the Interface between Host Genome and Mobile Genetic Elements.Frontiers in microbiology · 2017Article
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- Small RNAs: essential regulators of gene expression and defenses against environmental stresses in plants.Wiley interdisciplinary reviews. RNA · 2016Review
- Transpositional shuffling and quality control in male germ cells to enhance evolution of complex organisms.Annals of the New York Academy of Sciences · 2015Article
- Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving theTranslational neuroscience · 2015Review
- Chromatin-remodeling factors mediate the balance of sense-antisense transcription at the FGF2 locus.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Article
- Contribution of natural antisense transcription to an endogenous siRNA signature in human cells.BMC genomics · 2014Article
- Mechanisms of small RNA generation from cis-NATs in response to environmental and developmental cues.Molecular plant · 2013Review
- Integrative proteomic and transcriptomic analyses reveal multiple post-transcriptional regulatory mechanisms of mouse spermatogenesis.Molecular & cellular proteomics : MCP · 2013Article
- Biological functions of natural antisense transcripts.BMC biology · 2013Article
- The functions of natural antisense transcripts.Essays in biochemistry · 2013Review
- Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells.Nature structural & molecular biology · 2012Article
- Genome-wide analysis of plant nat-siRNAs reveals insights into their distribution, biogenesis and function.Genome biology · 2012Article
- Endogenous siRNAs and noncoding RNA-derived small RNAs are expressed in adult mouse hippocampus and are up-regulated in olfactory discrimination training.RNA (New York, N.Y.) · 2011Article
- What are natural antisense transcripts good for?Biochemical Society transactions · 2010Review
- Consistent annotation of gene expression arrays.BMC genomics · 2010Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Natural antisense transcripts (NATs) are important regulators of gene expression. Recently, a link between antisense transcription and the formation of endo-siRNAs has emerged. We investigated the bi-directionally transcribed Na/phosphate cotransporter gene (Slc34a1) under the aspect of endo-siRNA processing. Mouse Slc34a1 produces an antisense transcript that represents an alternative splice product of the Pfn3 gene located downstream of Slc34a1. The antisense transcript is prominently found in testis and in kidney. Co-expression of in vitro synthesized sense/antisense transcripts in Xenopus oocytes indicated processing of the overlapping transcripts into endo-siRNAs in the nucleus. Truncation experiments revealed that an overlap of at least 29 base-pairs is required to induce processing. We detected endo-siRNAs in mouse tissues that co express Slc34a1 sense/antisense transcripts by northern blotting. The orientation of endo-siRNAs was tissue specific in mouse kidney and testis. In kidney where the Na/phosphate cotransporter fulfils its physiological function endo-siRNAs complementary to the NAT were detected, in testis both orientations were found. Considering the wide spread expression of NATs and the gene silencing potential of endo-siRNAs we hypothesized a genome-wide link between antisense transcription and monoallelic expression. Significant correlation between random imprinting and antisense transcription could indeed be established. Our findings suggest a novel, more general role for NATs in gene regulation.
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