ArticleMolecular immunology2009
Novel nonclassical MHC class Ib genes associated with CD8 T cell development and thymic tumors.
Article in Molecular immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- The Amphibian Major Histocompatibility Complex-A Review and Future Outlook.Journal of molecular evolution · 2025Review
- Larval T Cells Are Functionally Distinct from Adult T Cells in Xenopus laevis.ImmunoHorizons · 2023Article
- γδ T, NKT, and MAIT Cells During Evolution: Redundancy or Specialized Functions?Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- A Glimpse of the Peptide Profile Presentation byJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Distinct MHC class I-like interacting invariant T cell lineage at the forefront of mycobacterial immunity uncovered inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Coevolution of MHC genes (LMP/TAP/class Ia, NKT-class Ib, NKp30-B7H6): lessons from cold-blooded vertebrates.Immunological reviews · 2015Review
- Evolution of nonclassical MHC-dependent invariant T cells.Cellular and molecular life sciences : CMLS · 2014Review
- A prominent role for invariant T cells in the amphibian Xenopus laevis tadpoles.Immunogenetics · 2014Review
- A critical role of non-classical MHC in tumor immune evasion in the amphibian Xenopus model.Carcinogenesis · 2014Article
- Article
- Nonclassical MHC class I-dependent invariant T cells are evolutionarily conserved and prominent from early development in amphibians.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Evolution by selection, recombination, and gene duplication in MHC class I genes of two Rhacophoridae species.BMC evolutionary biology · 2013Article
- Hsp72 mediates stronger antigen-dependent non-classical MHC class Ib anti-tumor responses than hsc73 in Xenopus laevis.Cancer immunity · 2013Article
- The genus Xenopus as a multispecies model for evolutionary and comparative immunobiology of the 21st century.Developmental and comparative immunology · 2011Review
- Remarkable conservation of distinct nonclassical MHC class I lineages in divergent amphibian species.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Comparative and developmental study of the immune system in Xenopus.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Review
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
In jawed vertebrates, the heterogeneous nonclassical MHC class Ib (class Ib) gene family encodes molecules structurally similar to classical MHC class Ia (class Ia) but with more limited tissue distribution and lower polymorphism. In mammals, class Ib gene products are involved in stress responses, malignancy and differentiation of intrathymic CD8 T cells. The frog Xenopus laevis possesses at least 20 class Ib genes (XNCs), and 9 subfamilies have been defined so far. We have characterized two novel subfamilies, XNC10 and XNC11. XNC10 is phylogenetically and structurally distinct from both class Ia and other XNC genes. Besides thymic lymphoid tumors, XNC10 is preferentially expressed by circulating T cells and thymocytes of the CD8 lineage both in adult and in larvae from the onset of thymus organogenesis. XNC11 is expressed only by thymocytes and upregulated by several thymic lymphoid tumors. These data provide the first evidence of the expression of any class Ib genes in Xenopus larvae, and suggests evolutionary relationships between certain class Ib genes, malignancy and CD8 T cell ontogeny.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.