ArticleVeterinary research
Rapid and widely disseminated acute phase protein response after experimental bacterial infection of pigs.
Article in Veterinary research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 93 citations in OpenAlex.
- Beyond Lesions: Systemic Inflammatory and Metabolic Characterization of Swine Inflammation and Necrosis Syndrome.Animals : an open access journal from MDPI · 2026Article
- Serum Amyloid A: A Double-Edged Sword in Health and Disease.International journal of molecular sciences · 2025Review
- Diagnostic utility of acute phase proteins and their ability to guide antibiotic usage in pigs, horses, and cattle: a mapping review.Acta veterinaria Scandinavica · 2024Review
- Dietary seaweed (Saccharina latissima) supplementation in pigs induces localized immunomodulatory effects and minor gut microbiota changes during intestinal helminth infection.Scientific reports · 2023Article
- Serotonin receptors and their association with the immune system in the gastrointestinal tract of weaning piglets.Porcine health management · 2022Article
- Dynamic immune response characteristics of piglets infected with Actinobacillus pleuropneumoniae through omic.AMB Express · 2021Article
- Fermented rye with Agaricus subrufescens and mannan-rich hydrolysate based feed additive to modulate post-weaning piglet immune response.Porcine health management · 2021Article
- A brief, highly selective history of acute phase proteins as indicators of infection, inflammation and injury.Inflammopharmacology · 2021Review
- Weaning causes a prolonged but transient change in immune gene expression in the intestine of piglets.Journal of animal science · 2021Article
- Parasite-Probiotic Interactions in the Gut:Frontiers in immunology · 2021Article
- Mucosal Barrier and Th2 Immune Responses Are Enhanced by Dietary Inulin in Pigs Infected WithFrontiers in immunology · 2018Article
- IFN-λ and microRNAs are important modulators of the pulmonary innate immune response against influenza A (H1N2) infection in pigs.PloS one · 2018Article
- Host-pathogen interplay at primary infection sites in pigs challenged with Actinobacillus pleuropneumoniae.BMC veterinary research · 2017Article
- Frequency of Th17 cells correlates with the presence of lung lesions in pigs chronically infected with Actinobacillus pleuropneumoniae.Veterinary research · 2017Article
- Expression Dynamics of Innate Immunity in Influenza Virus-Infected Swine.Frontiers in veterinary science · 2017Article
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- Activation of innate immune genes in caprine blood leukocytes after systemic endotoxin challenge.BMC veterinary research · 2016Article
- Late regulation of immune genes and microRNAs in circulating leukocytes in a pig model of influenza A (H1N2) infection.Scientific reports · 2016Article
- The Pig PeptideAtlas: A resource for systems biology in animal production and biomedicine.Proteomics · 2016Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The acute phase protein response is a well-described generalized early host response to tissue injury, inflammation and infection, observed as pronounced changes in the concentrations of a number of circulating serum proteins. The biological function of this response and its interplay with other parts of innate host defence reactions remain somewhat elusive. In order to gain new insight into this early host defence response in the context of bacterial infection we studied gene expression changes in peripheral lymphoid tissues as compared to hepatic expression changes, 14-18 h after lung infection in pigs. The lung infection was established with the pig specific respiratory pathogen Actinobacillus pleuropneumoniae. Quantitative real-time PCR based expression analysis were performed on samples from liver, tracheobronchial lymph node, tonsils, spleen and on blood leukocytes, supplemented with measurements of interleukin-6 and selected acute phase proteins in serum. C-reactive protein and serum amyloid A were clearly induced 14-18 h after infection. Extrahepatic expression of acute phase proteins was found to be dramatically altered as a result of the lung infection with an extrahepatic acute phase protein response occurring concomitantly with the hepatic response. This suggests that the acute phase protein response is a more disseminated systemic response than previously thought. The current study provides to our knowledge the first example of porcine extrahepatic expression and regulation of C-reactive protein, haptoglobin, fibrinogen, pig major acute phase protein, and transferrin in peripheral lymphoid tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.