ArticleBMC molecular biology2009
Sex-different and growth hormone-regulated expression of microRNA in rat liver.
Article in BMC molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Exogenous glucocorticoid dose impacts circulating microRNA expression in patients with adrenal insufficiency due to 21-hydroxylase deficiency.Frontiers in endocrinology · 2026Article
- β-Carotene Impacts the Liver MicroRNA Profile in a Sex-Specific Manner in Mouse Offspring of Western Diet-Fed Mothers: Results from Microarray Analysis by Direct Hybridization.International journal of molecular sciences · 2024Article
- Regulation of the somatotropic axis by MYC-mediated miRNA repression.Frontiers in cell and developmental biology · 2023Article
- Functional Roles of Sex-Biased, Growth Hormone-Regulated MicroRNAs miR-1948 and miR-802 in Young Adult Mouse Liver.Endocrinology · 2018Article
- Sex-biased microRNA expression in mammals and birds reveals underlying regulatory mechanisms and a role in dosage compensation.Genome research · 2017Article
- Growth hormone: a newly identified developmental organizer.The Journal of endocrinology · 2017Article
- Regulation of hepatic microRNA expression by hepatocyte nuclear factor 4 alpha.World journal of hepatology · 2017Article
- Diet, gonadal sex, and sex chromosome complement influence white adipose tissue miRNA expression.BMC genomics · 2017Article
- The two faces of miR-29.Journal of cardiovascular medicine (Hagerstown, Md.) · 2015Review
- Sexual dimorphism in autoimmunity.The Journal of clinical investigation · 2015Review
- The influence of early life nutrition on epigenetic regulatory mechanisms of the immune system.Nutrients · 2014Review
- Independent effects of sham laparotomy and anesthesia on hepatic microRNA expression in rats.BMC research notes · 2014Article
- Differential microRNA profile and post-transcriptional regulation exist in systemic lupus erythematosus patients with distinct autoantibody specificities.Journal of clinical immunology · 2014Article
- Article
- Sexual dimorphism of miRNA expression: a new perspective in understanding the sex bias of autoimmune diseases.Therapeutics and clinical risk management · 2014Review
- Sex differences in the expression of lupus-associated miRNAs in splenocytes from lupus-prone NZB/WF1 mice.Biology of sex differences · 2013Article
- MicroRNAs synergistically regulate milk fat synthesis in mammary gland epithelial cells of dairy goats.Gene expression · 2013Article
- Gender-specific reduction of estrogen-sensitive small RNA, miR-30b, in subjects with schizophrenia.Schizophrenia bulletin · 2012Article
- miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- MicroRNAs show diverse and dynamic expression patterns in multiple tissues of Bombyx mori.BMC genomics · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroRNAs (miRNAs) are short non-coding RNAs playing an important role in post-transcriptional regulation of gene expression. We have previously shown that hepatic transcript profiles are different between males and females; that some of these differences are under the regulation of growth hormone (GH); and that mild starvation diminishes some of the differences. In this study, we tested if hepatic miRNAs are regulated in a similar manner.
resultsUsing microarrays, miRNA screening was performed to identify sex-dependent miRNAs in rat liver. Out of 324 unique probes on the array, 254 were expressed in the liver and eight (3% of 254) of those were found to be different between the sexes. Among the eight putative sex-different miRNAs, only one female-predominant miRNA (miR-29b) was confirmed using quantitative real-time PCR. Furthermore, 1 week of continuous GH-treatment in male rats reduced the levels of miR-451 and miR-29b, whereas mild starvation (12 hours) raised the levels of miR-451, miR-122a and miR-29b in both sexes. The biggest effects were obtained on miR-29b with GH-treatment.
conclusionWe conclude that hepatic miRNA levels depend on the hormonal and nutritional status of the animal and show that miR-29b is a female-predominant and GH-regulated miRNA in rat liver.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.