ArticleMolecular plant pathology2009
Structural and functional investigation of a secreted chorismate mutase from the plant-parasitic nematode Heterodera schachtii in the context of related enzymes from diverse origins.
Article in Molecular plant pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Syncytium Induced by Plant-Parasitic Nematodes.Results and problems in cell differentiation · 2024Review
- Engineered coumarin accumulation reduces mycotoxin-induced oxidative stress and disease susceptibility.Plant biotechnology journal · 2023Article
- Pathogens pulling the strings: Effectors manipulating salicylic acid and phenylpropanoid biosynthesis in plants.Molecular plant pathology · 2021Review
- Complete, closed and curated genome sequences ofMicrobial genomics · 2021Article
- Sedentary Plant-Parasitic Nematodes Alter Auxin Homeostasis via Multiple Strategies.Frontiers in plant science · 2021Review
- Chorismate mutase and isochorismatase, two potential effectors of the migratory nematode Hirschmanniella oryzae, increase host susceptibility by manipulating secondary metabolite content of rice.Molecular plant pathology · 2020Article
- Big Genes, Small Effectors: Pea Aphid Cassette Effector Families Composed From Miniature Exons.Frontiers in plant science · 2020Article
- Phytoparasitic Nematode Control of Plant Hormone Pathways.Plant physiology · 2019Review
- The genome of the soybean cyst nematode (Heterodera glycines) reveals complex patterns of duplications involved in the evolution of parasitism genes.BMC genomics · 2019Article
- Heterodera glycines utilizes promiscuous spliced leaders and demonstrates a unique preference for a species-specific spliced leader over C. elegans SL1.Scientific reports · 2019Article
- Functions of Flavonoids in Plant⁻Nematode Interactions.Plants (Basel, Switzerland) · 2018Review
- The plant-parasitic cyst nematode effector GLAND4 is a DNA-binding protein.Molecular plant pathology · 2018Article
- Nematode-secreted peptides and host factor mimicry.Journal of experimental botany · 2018Article
- Alienness: Rapid Detection of Candidate Horizontal Gene Transfers across the Tree of Life.Genes · 2017Article
- Transgenic soybean overexpressing GmSAMT1 exhibits resistance to multiple-HG types of soybean cyst nematode Heterodera glycines.Plant biotechnology journal · 2016Article
- Plant-Pathogen Effectors: Cellular Probes Interfering with Plant Defenses in Spatial and Temporal Manners.Annual review of phytopathology · 2016Review
- Horizontal Gene Transfer Contributes to the Evolution of Arthropod Herbivory.Genome biology and evolution · 2016Article
- Cellular Signaling Pathways and Posttranslational Modifications Mediated by Nematode Effector Proteins.Plant physiology · 2015Review
- Intervention of Phytohormone Pathways by Pathogen Effectors.The Plant cell · 2014Review
- Plant cell wall lignification and monolignol metabolism.Frontiers in plant science · 2013Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this article, we present the cloning of Hscm1, a gene for chorismate mutase (CM) from the beet cyst nematode Heterodera schachtii. CM is a key branch-point enzyme of the shikimate pathway, and secondary metabolites that arise from this pathway control developmental programmes and defence responses of the plant. By manipulating the plant's endogenous shikimate pathway, the nematode can influence the plant physiology for its own benefit. Hscm1 is a member of the CM gene family and is expressed during the pre-parasitic and parasitic stages of the nematode's life cycle. In situ mRNA hybridization reveals an expression pattern specific to the subventral and dorsal pharyngeal glands. The predicted protein has a signal peptide for secretion in addition to two domains. The N-terminal domain of the mature protein, which is only found in cyst nematodes, contains six conserved cysteine residues, which may reflect the importance of disulphide bond formation for protein stabilization. The C-terminal domain holds a single catalytic site and has similarity to secreted CMs of pathogenic bacteria, classifying HsCM1 as an AroQ(gamma) enzyme. The presumed catalytic residues are discussed in detail, and genetic complementation experiments indicate that the C-terminal domain is essential for enzyme activity. Finally, we show how the modular design of the protein is mirrored in the genomic sequence by the intron/exon organization, suggesting exon shuffling as a mechanism for the evolutionary assembly of this protein.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.