ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Regulation of the Caenorhabditis elegans posterior Hox gene egl-5 by microRNA and the polycomb-like gene sop-2.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- The multifaceted roles of microRNAs in differentiation.Current opinion in cell biology · 2020Review
- Dysregulation of Neuronal Gαo Signaling by Graphene Oxide in Nematode Caenorhabditis elegans.Scientific reports · 2019Article
- Recent Molecular Genetic Explorations ofGenetics · 2018Article
- Dual repression of endocytic players by ESCC microRNAs and the Polycomb complex regulates mouse embryonic stem cell pluripotency.Scientific reports · 2017Article
- The mir-51 family of microRNAs functions in diverse regulatory pathways in Caenorhabditis elegans.PloS one · 2012Article
- EGL-5/ABD-B plays an instructive role in male cell fate determination in the C. elegans somatic gonad.Developmental biology · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In Caenorhabditis elegans, the domains of Hox gene expression are controlled by the novel global regulatory gene sop-2. We identified a region located 3' of the Hox gene egl-5 that promotes ectopic expression of an egl-5 reporter gene in a sop-2 mutant. SOP-2 could directly block positive regulatory factors acting in this region, or it could block their expression. We identified three possible miRNA binding sites within the egl-5 3' untranslated region (UTR). Cognate microRNAs are expressed in relevant tissues and can block egl-5 expression when expressed from a transgene. Mutation of the putative binding sites in the egl-5 3'UTR resulted in a modest degree of misexpression of a minimal egl-5 reporter gene, suggesting that microRNAs may contribute to the tight restriction of egl-5 expression to particular cell lineages.
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Registered trials
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