Trial reportNutrition and cancer2009
Association of leptin, 25-hydroxyvitamin D, and parathyroid hormone in women.
Trial report in Nutrition and cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Vitamin D and serum leptin: a systematic review and meta-analysis of observational studies and randomized controlled trials.European journal of clinical nutrition · 2017Pooled it
- Relationship between vitamin D, parathyroid hormone, and bone health.The Journal of clinical endocrinology and metabolism · 2011Pooled it
- Vitamin D supplementation increases adipokine concentrations in overweight or obese adults.European journal of nutrition · 2020Trial
- Consumption of vitamin D-fortified yogurt drink increased leptin and ghrelin levels but reduced leptin to ghrelin ratio in type 2 diabetes patients: a single blind randomized controlled trial.European journal of nutrition · 2017Trial
- Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function: the Sun Exposure and Vitamin D Supplementation (SEDS) Study.BMC public health · 2015Trial
- Relationship between vitamin D deficiency, bone remodelling and iron status in iron-deficient young women consuming an iron-fortified food.European journal of nutrition · 2013Trial
- Correlates of 25-hydroxyvitamin D and breast cancer stage in the Women's Healthy Eating and Living Study.Nutrition and cancer · 2013Trial
- 25-Hydroxy vitamin-D, obesity, and associated variables as predictors of breast cancer risk and tamoxifen benefit in NSABP-P1.Breast cancer research and treatment · 2012Trial
- Effects of vitamin D3 and calcium supplementation on serum levels of tocopherols, retinol, and specific vitamin D metabolites.Nutrition and cancer · 2012Trial
- Vitamin D and hyperparathyroidism in obesity.The Journal of clinical endocrinology and metabolism · 2011Trial
- Associations between obesity and serum lipid-soluble micronutrients among premenopausal women.Nutrition research (New York, N.Y.) · 2010Trial
- From nerve to bone: a tale of autonomic nervous system, bone cells, and beyond.Military Medical Research · 2026Review
- Review
- Explorative research on glucolipid metabolism and levels of adipokines in pseudohypoparathyroidism type 1 patients.Orphanet journal of rare diseases · 2023Article
- Excessive Pregestational Weight and Maternal Obstetric Complications: The Role of Adipokines.International journal of molecular sciences · 2023Review
- Serum 25-hydroxyvitamin D levels and the risk of idiopathic central precocious puberty in girls.Clinics (Sao Paulo, Brazil) · 2023Article
- Pivotal role of vitamin D in mitochondrial health, cardiac function, and human reproduction.EXCLI journal · 2022Review
- Vitamin D and Obesity: Current Evidence and Controversies.Current obesity reports · 2021Review
- Update on the Crosstalk Between Adipose Tissue and Mineral Balance in General Population and Chronic Kidney Disease.Frontiers in pediatrics · 2021Review
- Study of low vitamin D among children with anorexia in Sulaymaniyah, Kurdistan region, Iraq during summer months.Saudi medical journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Vitamin D deficiency and adipocytokines have been implicated in the etiology of aging-related diseases such as cancer, osteoporosis, and diseases of the cardiovascular system. The association between elevated parathyroid hormone (PTH) and low 25-hydroxyvitamin D (25-OH-VitD) in plasma is used to define vitamin D deficiency, yet their associated mechanistic pathways are unclear. Utilizing plasma samples from women in a previous intervention study, we measured plasma 25-OH-VitD, leptin, adiponectin, PTH, and lipid levels. We observed strong positive associations for leptin with PTH, gamma -tocopherol, and body mass index (BMI) and inverse associations with 25-OH-VitD and adiponectin. Although commonly accepted that vitamin D deficiency causes hyperparathyroidism, we observed this association primarily in individuals with elevated leptin levels, suggesting that leptin may be an important modifier of this effect consistent with 25-OH-VitD-mediated inhibition of leptin. Leptin was highly correlated with the BMI/25-OH-VitD ratio (r = 0.80; P < 0.0001), consistent with a model in which BMI (adiposity) and 25-OH-VitD are the primary determinants of circulating leptin and PTH levels. This model may explain the failure of some studies to observe elevated PTH in vitamin D deficient adolescents and provides important insight into epidemiological studies exploring the associations of these individual biomarkers with chronic disease risk and mortality.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.