ReviewBiochemistry and cell biology = Biochimie et biologie cellulaire2009
A lot about a little dot - lessons learned from Drosophila melanogaster chromosome 4.
Review in Biochemistry and cell biology = Biochimie et biologie cellulaire, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Analyses of POL30 (PCNA) reveal positional effects in transient repression or bi-modal active/silent state at the sub-telomeres of S. cerevisiae.Epigenetics & chromatin · 2023Article
- Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome.PLoS genetics · 2021Article
- Complex Evolutionary History of the Y Chromosome in Flies of the Drosophila obscura Species Group.Genome biology and evolution · 2020Article
- Molecular and genetic organization of bands and interbands in the dot chromosome of Drosophila melanogaster.Chromosoma · 2019Article
- Retrotransposons Are the Major Contributors to the Expansion of theG3 (Bethesda, Md.) · 2017Article
- Sensitivity of Allelic Divergence to Genomic Position: Lessons from the Drosophila tan Gene.G3 (Bethesda, Md.) · 2016Article
- The hnRNP A1 homolog Hrb87F/Hrp36 is important for telomere maintenance in Drosophila melanogaster.Chromosoma · 2016Article
- Unique transposon landscapes are pervasive across Drosophila melanogaster genomes.Nucleic acids research · 2015Article
- The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres.PLoS genetics · 2015Article
- Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.G3 (Bethesda, Md.) · 2015Article
- Dosage Compensation of X-Linked Muller Element F Genes but Not X-Linked Transgenes in the Australian Sheep Blowfly.PloS one · 2015Article
- Normal segregation of a foreign-species chromosome during Drosophila female meiosis despite extensive heterochromatin divergence.Genetics · 2015Article
- Map of open and closed chromatin domains in Drosophila genome.BMC genomics · 2014Article
- Investigation of the chromosome regions with significant affinity for the nuclear envelope in fruit fly--a model based approach.PloS one · 2014Article
- Combinatorial modeling of chromatin features quantitatively predicts DNA replication timing in Drosophila.PLoS computational biology · 2014Article
- A course-based research experience: how benefits change with increased investment in instructional time.CBE life sciences education · 2014Article
- Article
- HP1a, Su(var)3-9, SETDB1 and POF stimulate or repress gene expression depending on genomic position, gene length and expression pattern in Drosophila melanogaster.Nucleic acids research · 2013Article
- RNA editing regulates transposon-mediated heterochromatic gene silencing.Nature communications · 2013Article
- Heterochromatin protein 1a is required for an open chromatin structure.Transcription · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The fourth chromosome of Drosophila melanogaster has a number of unique properties that make it a convenient model for the study of chromatin structure. Only 4.2 Mb overall, the 1.2 Mb distal arm of chromosome 4 seen in polytene chromosomes combines characteristics of heterochromatin and euchromatin. This domain has a repeat density of ~35%, comparable to some pericentric chromosome regions, while maintaining a gene density similar to that of the other euchromatic chromosome arms. Studies of position-effect variegation have revealed that heterochromatic and euchromatic domains are interspersed on chromosome 4, and both cytological and biochemical studies have demonstrated that chromosome 4 is associated with heterochromatic marks, such as heterochromatin protein 1 and histone 3 lysine 9 methylation. Chromosome 4 is also marked by POF (painting-of-fourth), a chromosome 4-specific chromosomal protein, and utilizes a dedicated histone methyltransferase, EGG. Studies of chromosome 4 have helped to shape our understanding of heterochromatin domains and their establishment and maintenance. In this review, we provide a synthesis of the work to date and an outlook to the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.