Evidence map›Paper›PMID 19234479›Full record

ReviewNature reviews. Molecular cell biology2009

ABC transporters: the power to change.

Douglas C Rees, Eric Johnson, Oded Lewinson

Abstract readReview
In one paragraph

Review in Nature reviews. Molecular cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 679 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
679citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

679 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  16. Propionate oxidation byApplied and environmental microbiology · 2026
    Article
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619 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Douglas C ReesDivision of Chemistry and Chemical Engineering 114-96, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA. dcrees@caltech.edu
Eric Johnson
Oded Lewinson

Funding

Crystallographic Studies of Electron Tranfer ProteinsR37GM045162 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI REES, DOUGLAS CHARLES · 2003 to 2012
$3.1M
CRYSTALLOGRAPHIC STUDIES OF ELECTRON TRANSFER PROTEINSR01GM045162 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI REES, DOUGLAS CHARLES · 1991 to 2018
$2.2M
Howard Hughes Medical InstituteNIGMS NIH HHS GM45162NIGMS NIH HHS R01 GM045162NIGMS NIH HHS R37 GM045162
6 · The paper itself

Abstract

ATP-binding cassette (ABC) transporters constitute a ubiquitous superfamily of integral membrane proteins that are responsible for the ATP-powered translocation of many substrates across membranes. The highly conserved ABC domains of ABC transporters provide the nucleotide-dependent engine that drives transport. By contrast, the transmembrane domains that create the translocation pathway are more variable. Recent structural advances with prokaryotic ABC transporters have provided a qualitative molecular framework for deciphering the transport cycle. An important goal is to develop quantitative models that detail the kinetic and molecular mechanisms by which ABC transporters couple the binding and hydrolysis of ATP to substrate translocation.

Indexed as

AnimalsATP-Binding Cassette TransportersBinding SitesBiological TransportDimerizationHumansKineticsModels, MolecularProtein BindingProtein Structure, TertiaryATP-Binding Cassette Transporters

Identifiers

PMID19234479
PMCPMC2830722

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.