ArticleNature neuroscience2009
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse.
Article in Nature neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02623400 (The Effect of Perinatal Stress on the Development of Preterm Infants), which is not on this map. Cited by 1,210 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Perinatal Stress on the Development of Preterm Infants
Who cites it
1,210 citing papers in PubMed, 5 syntheses or guidelines pooled it, 3,453 citations in OpenAlex.
- Epigenome-wide association study meta-analysis of wellbeing.Clinical epigenetics · 2026Pooled it
- The impact of adverse childhood experiences on DNA methylation age: a systematic review and meta-analysis.Clinical epigenetics · 2026Pooled it
- Developing a translational research framework for MDD: combining biomolecular mechanisms with a spiraling risk factor model.Frontiers in psychiatry · 2024Pooled it
- The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis.British journal of anaesthesia · 2023Pooled it
- Perinatal stress and methylation of theEpigenetics · 2022Pooled it
- Peripheral miRNA profiling identifies therapy-specific biological trajectories in the treatment of cognitive dysfunction in depression: an exploratory mechanistic study.Scientific reports · 2026Trial
- Trial
- A cluster-randomized trial of water, sanitation, handwashing and nutritional interventions on stress and epigenetic programming.Nature communications · 2024Trial
- Childhood adversity, adulthood adversity and suicidal ideation in Chinese patients with major depressive disorder: in line with stress sensitization.European archives of psychiatry and clinical neuroscience · 2022Trial
- The epigenetic archaeology of human-dog companionship.Epigenetics · 2026Review
- Race, Diet, and Cardiometabolic Risk in US Young Adults: A Biosocial Framework Integrating Biological Mechanisms and Structural Inequities Toward Precision Nutrition.Current nutrition reports · 2026Review
- Antidepressant effects of Gardeniae Fructus on chronic unpredictable mild stress model mice: involvement of DNMT3B-mediated epigenetic regulation of GR in the prefrontal cortex.Journal of natural medicines · 2026Article
- Parvalbumin interneurons under stress: converging mechanisms of vulnerability.The international journal of neuropsychopharmacology · 2026Review
- Glucocorticoid receptor gene (Neurobiology of stress · 2026Article
- Epigenetic dysregulation in depression: molecular mechanisms, clinical biomarkers, and therapeutic opportunities.Journal of translational medicine · 2026Review
- Epigenetic Regulation of Modulatory Neurotransmitter System Integrity in the Aging Brain: A Scoping Review Across the Lifespan.Life (Basel, Switzerland) · 2026Review
- The Impact of Childhood Trauma on Neuropsychological Disorders and Its Intergenerational Transmission Mechanisms.Behavioral sciences (Basel, Switzerland) · 2026Review
- The evolution and frontiers of global pediatric glucocorticoids research: an in-depth analysis based on 28 years of bibliometrics.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Practitioner Review: Infant mental health meets cell and molecular biology - a look to the future.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Maternal separation increases anxiety-like phenotypes, fear responses, and altersNeurobiology of stress · 2026Article
1,150 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse alters HPA stress responses and increases the risk of suicide. We examined epigenetic differences in a neuron-specific glucocorticoid receptor (NR3C1) promoter between postmortem hippocampus obtained from suicide victims with a history of childhood abuse and those from either suicide victims with no childhood abuse or controls. We found decreased levels of glucocorticoid receptor mRNA, as well as mRNA transcripts bearing the glucocorticoid receptor 1F splice variant and increased cytosine methylation of an NR3C1 promoter. Patch-methylated NR3C1 promoter constructs that mimicked the methylation state in samples from abused suicide victims showed decreased NGFI-A transcription factor binding and NGFI-A-inducible gene transcription. These findings translate previous results from rat to humans and suggest a common effect of parental care on the epigenetic regulation of hippocampal glucocorticoid receptor expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.