ArticleInvestigative ophthalmology & visual science2009
Optic neuritis in different strains of mice by a recombinant HSV-1 expressing murine interleukin-2.
Article in Investigative ophthalmology & visual science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 20 citations in OpenAlex.
- HSV-1 Infection Differentially Modulates NPY and VIP Neuropeptide Expression in the Mouse Brain and in Human Neuronal Cells.International journal of molecular sciences · 2026Article
- Divergent roles of macrophage subsets, FoxP3, and IL-17A in HSV-1-induced CNS pathology.PLoS pathogens · 2025Article
- The importance of IFNα2A (Roferon-A) in HSV-1 latency and T cell exhaustion in ocularly infected mice.PLoS pathogens · 2024Article
- IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination.Frontiers in immunology · 2023Article
- Protocol for a mouse CNS demyelination model induced by a combination of HSV-1 and IL-2.STAR protocols · 2021Article
- Impact of a Demyelination-Inducing Central Nervous System Virus on Expression of Demyelination Genes in Type 2 Lymphoid Cells.Journal of virology · 2021Article
- Type 2 Innate Lymphoid Cells Induce CNS Demyelination in an HSV-IL-2 Mouse Model of Multiple Sclerosis.iScience · 2020Article
- Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice.PLoS pathogens · 2017Article
- Optic Neuritis: A Model for the Immuno-pathogenesis of Central Nervous System Inflammatory Demyelinating Diseases.Current immunology reviews · 2015Article
- A comparative study of experimental mouse models of central nervous system demyelination.Gene therapy · 2014Article
- Aging-related changes of optic nerve of Wistar albino rats.Age (Dordrecht, Netherlands) · 2014Article
- Role of interleukin-2 and herpes simplex virus 1 in central nervous system demyelination in mice.Journal of virology · 2013Article
- The effect of mouse strain on herpes simplex virus type 1 (HSV-1) infection of the central nervous system (CNS).Herpesviridae · 2012Article
- Article
- Use of cytokine immunotherapy to block CNS demyelination induced by a recombinant HSV-1 expressing IL-2.Gene therapy · 2011Article
- Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs.Investigative ophthalmology & visual science · 2011Article
- IL-2 suppression of IL-12p70 by a recombinant HSV-1 expressing IL-2 induces T-cell auto-reactivity and CNS demyelination.PloS one · 2011Article
- Visual abnormalities associated with enhanced optic nerve myelination.Brain research · 2011Article
- Ocular infection of mice with an avirulent recombinant HSV-1 expressing IL-4 and an attenuated HSV-1 strain generates virulent recombinants in vivo.Molecular vision · 2010Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThe authors have shown previously that a recombinant HSV-1 that constitutively expresses two copies of murine IL-2 (HSV-IL-2) induces demyelination by activated CD8(+) T cells in the brain and spinal cord of ocularly infected female BALB/c mice. The present study was conducted to determine whether the ocular infection with this recombinant virus induces optic neuritis independent of virus dose, major histocompatibility complex (MHC) background, or sex.
methodsFemale BALB/c, C57BL/6, SJL/6, and 129SVE mice and male BALB/c mice were ocularly infected with different doses of recombinant HSV-IL-2 virus. Demyelination of optic nerves in infected mice was monitored histologically using Luxol fast blue staining and by measurement of visual-evoked cortical potentials (VECPs).
resultsBoth focal and diffuse regions of demyelination of the optic nerves were observed in the HSV-IL-2-infected mice as early as day 10 after infection and as late as day 60 after infection (the final experimental time point) in all strains of mice tested. Optic nerve demyelination was not observed in control mice ocularly infected with HSV-IL-4 or wild-type HSV-1. VECP responses were delayed significantly in the HSV-IL-2-infected mice compared with mice infected with control viruses.
conclusionsThe results demonstrate for the first time that a combination of viral infection and constitutive expression of IL-2, but not IFN-gamma or IL-4, can result in demyelination and visual impairment in the optic nerves of ocularly infected mice.
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