ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Rapid dendritic cell mobilization to the large intestinal epithelium is associated with resistance to Trichuris muris infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Basophil responses in susceptible AKR mice upon infection with the intestinal helminth parasite Trichuris muris.Parasite immunology · 2023Article
- Food for thought - ILC metabolism in the context of helminth infections.Mucosal immunology · 2022Review
- Echinococcus multilocularis specific antibody, systemic cytokine, and chemokine levels, as well as antigen-specific cellular responses in patients with progressive, stable, and cured alveolar echinococcosis: A 10-year follow-up.PLoS neglected tropical diseases · 2022Article
- The Role of the Intestinal Epithelium in the "Weep and Sweep" Response during Gastro-Intestinal Helminth Infections.Animals : an open access journal from MDPI · 2022Review
- Review
- The role of βBMC immunology · 2021Article
- Goblet cell associated antigen passages support the induction and maintenance of oral tolerance.Mucosal immunology · 2020Article
- Differential Expression of Soluble Receptor for Advanced Glycation End-products in Mice Susceptible or Resistant to Chronic Colitis.Inflammatory bowel diseases · 2020Article
- The Essential Role Played by B Cells in Supporting Protective Immunity AgainstFrontiers in immunology · 2019Article
- Goblet cells: multifaceted players in immunity at mucosal surfaces.Mucosal immunology · 2018Review
- The circadian regulator BMAL1 programmes responses to parasitic worm infection via a dendritic cell clock.Scientific reports · 2018Article
- Antibiotics promote the sampling of luminal antigens and bacteria via colonic goblet cell associated antigen passages.Gut microbes · 2017Article
- P2X7 receptor-dependent tuning of gut epithelial responses to infection.Immunology and cell biology · 2017Article
- Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway.Journal of neuroinflammation · 2016Article
- Postbiotic Modulation of Retinoic Acid Imprinted Mucosal-like Dendritic Cells by Probiotic Lactobacillus reuteri 17938 In Vitro.Frontiers in immunology · 2016Article
- Heterogeneity across the murine small and large intestine.World journal of gastroenterology · 2014Review
- A role for the pattern recognition receptor Nod2 in promoting recruitment of CD103+ dendritic cells to the colon in response to Trichuris muris infection.Mucosal immunology · 2014Article
- Immunity to gastrointestinal nematodes: mechanisms and myths.Immunological reviews · 2014Review
- CX3CR1⁺ cells facilitate the activation of CD4 T cells in the colonic lamina propria during antigen-driven colitis.Mucosal immunology · 2014Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
The large intestine is a major site of infection and disease, yet little is known about how immunity is initiated within this site and the role of dendritic cells (DCs) in this process. We used the well-established model of Trichuris muris infection to investigate the innate response of colonic DCs in mice that are inherently resistant or susceptible to infection. One day postinfection, there was a significant increase in the number of immature colonic DCs in resistant but not susceptible mice. This increase was sustained at day 7 postinfection in resistant mice when the majority of the DCs were mature. There was no increase in DC numbers in susceptible mice until day 13 postinfection. In resistant mice, most colonic DCs were located in or adjacent to the epithelium postinfection. There were also marked differences in the expression of colonic epithelial chemokines in resistant mice and susceptible mice. Resistant mice had significantly increased levels of epithelium-derived CCL2, CCL3, CCL5, and CCL20 compared with susceptible mice. Furthermore, administering neutralizing CCL5 and CCL20 Abs to resistant mice prevented DC recruitment. This study provides clear evidence of differences in the kinetics of DC responses in hosts inherently resistant and susceptible to infection. DC responses in the colon correlate with resistance to infection. Differences in the production of DC chemotactic chemokines by colonic epithelial cells in response to infection in resistant vs susceptible mice may explain the different kinetics of the DC response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.