ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Autoreactive B cells in SLE, villains or innocent bystanders?Immunological reviews · 2019Review
- CD4+ T cells and CD40 participate in selection and homeostasis of peripheral B cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- B-lymphocyte tolerance and effector function in immunity and autoimmunity.Immunologic research · 2013Review
- A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.The Journal of clinical investigation · 2013Article
- Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.Nature immunology · 2013Article
- Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice.Blood · 2012Article
- Developmentally regulated expression of MEF2C limits the response to BCR engagement in transitional B cells.European journal of immunology · 2012Article
- Differential impact of Toll-like receptor signaling on distinct B cell subpopulations.Frontiers in bioscience (Landmark edition) · 2012Review
- The transcription factor Bright plays a role in marginal zone B lymphocyte development and autoantibody production.Molecular immunology · 2011Article
- WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.The Journal of experimental medicine · 2011Article
- Prolactin, systemic lupus erythematosus, and autoreactive B cells: lessons learnt from murine models.Clinical reviews in allergy & immunology · 2011Review
- Article
- Signalling crosstalk in B cells: managing worth and need.Nature reviews. Immunology · 2009Review
- B cell receptor-mediated sustained c-Rel activation facilitates late transitional B cell survival through control of B cell activating factor receptor and NF-kappaB2.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The signaling programs that enforce negative selection in early transitional (T1) B cells in response to BCR engagement remain poorly defined. We conducted a comprehensive comparison of BCR signaling in T1 vs follicular mature splenic B cells. T1, in contrast to follicular mature B cells, failed to express key NF-kappaB target genes in response to BCR engagement and exhibited a striking defect in assembly of an active transcriptional complex at the promoter of the survival and proliferative genes A1 and c-Myc. Surprisingly, and contrary to previous models, classical protein kinase C and IkappaB kinase activation, NF-kappaB nuclear translocation and DNA binding were intact in T1 B cells. Furthermore, despite a marked reduction in NFAT1 expression, differential NFAT or AP-1 activation cannot explain this transcriptional defect. Our combined findings demonstrate that T1 B cells are programmed for signal- and stage-specific "nuclear nonresponsiveness" upon encounter with self-Ags.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.