ArticleProceedings of the National Academy of Sciences of the United States of America2009
Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 62 citations in OpenAlex.
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- Serratia marcescens DUF1471-Containing Protein SrfN Is Needed for Adaptation to Acid and Oxidative Stresses.mSphere · 2022Article
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- A stress-induced block in dicarboxylate uptake and utilization inJournal of bacteriology · 2021Article
- Diversity inmBio · 2019Article
- Parallel evolution leading to impaired biofilm formation in invasive Salmonella strains.PLoS genetics · 2019Article
- Within-Host Adaptation Mediated by Intergenic Evolution in Pseudomonas aeruginosa.Genome biology and evolution · 2019Article
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- Bacterial 'Grounded' Prophages: Hotspots for Genetic Renovation and Innovation.Frontiers in genetics · 2019Article
- Temporal Regulation of aMolecular & cellular proteomics : MCP · 2017Article
- Transcriptomic Analyses Elucidate Adaptive Differences of Closely Related Strains of Pseudomonas aeruginosa in Fuel.Applied and environmental microbiology · 2017Article
- Evolution ofFrontiers in cellular and infection microbiology · 2017Review
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Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
The acquisition of DNA by horizontal gene transfer enables bacteria to adapt to previously unexploited ecological niches. Although horizontal gene transfer and mutation of protein-coding sequences are well-recognized forms of pathogen evolution, the evolutionary significance of cis-regulatory mutations in creating phenotypic diversity through altered transcriptional outputs is not known. We show the significance of regulatory mutation for pathogen evolution by mapping and then rewiring a cis-regulatory module controlling a gene required for murine typhoid. Acquisition of a binding site for the Salmonella pathogenicity island-2 regulator, SsrB, enabled the srfN gene, ancestral to the Salmonella genus, to play a role in pathoadaptation of S. typhimurium to a host animal. We identified the evolved cis-regulatory module and quantified the fitness gain that this regulatory output accrues for the bacterium using competitive infections of host animals. Our findings highlight a mechanism of pathogen evolution involving regulatory mutation that is selected because of the fitness advantage the new regulatory output provides the incipient clones.
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