ArticleProceedings of the National Academy of Sciences of the United States of America2009
Dynamics of the bacterial flagellar motor with multiple stators.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Structure and Dynamics of the Bacterial Flagellar Motor Complex.Biomolecules · 2024Review
- A physical mechanism underlying the torque generation of the bacterial flagellar motor.The European physical journal. E, Soft matter · 2022Article
- Modeling Bacterial Flagellar Motor With New Structure Information: Rotational Dynamics of Two Interacting Protein Nano-Rings.Frontiers in microbiology · 2022Article
- Statistics of pathogenic bacteria in the search of host cells.Nature communications · 2021Article
- Motile ghosts of the halophilic archaeon,Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Measurement of the Internal Frictional Drag of the Bacterial Flagellar Motor by Fluctuation Analysis.Biophysical journal · 2020Article
- Flagella-Driven Motility of Bacteria.Biomolecules · 2019Review
- Evaluation of the Duty Ratio of the Bacterial Flagellar Motor by Dynamic Load Control.Biophysical journal · 2019Article
- The Second Messenger c-di-GMP Adjusts Motility and Promotes Surface Aggregation of Bacteria.Biophysical journal · 2018Article
- Design principles and optimal performance for molecular motors under realistic constraints.Physical review. E · 2018Article
- Limiting (zero-load) speed of the rotary motor ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Torque, but not FliL, regulates mechanosensitive flagellar motor-function.Scientific reports · 2017Article
- Biophysical Characterization of Flagellar Motor Functions.Journal of visualized experiments : JoVE · 2017Article
- The Limiting Speed of the Bacterial Flagellar Motor.Biophysical journal · 2016Article
- Mechanics of torque generation in the bacterial flagellar motor.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Mechanism and kinetics of a sodium-driven bacterial flagellar motor.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Coupling between switching regulation and torque generation in bacterial flagellar motor.Physical review letters · 2012Article
- Physics of bacterial morphogenesis.Microbiology and molecular biology reviews : MMBR · 2011Review
- Noise characteristics of the Escherichia coli rotary motor.BMC systems biology · 2011Article
- Steps and bumps: precision extraction of discrete states of molecular machines.Biophysical journal · 2011Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bacterial flagellar motor drives the rotation of flagellar filaments and enables many species of bacteria to swim. Torque is generated by interaction of stator units, anchored to the peptidoglycan cell wall, with the rotor. Recent experiments [Yuan J, Berg HC (2008) Proc Natl Acad Sci USA 105:1182-1185] show that at near-zero load the speed of the motor is independent of the number of stators. Here, we introduce a mathematical model of the motor dynamics that explains this behavior based on a general assumption that the stepping rate of a stator depends on the torque exerted by the stator on the rotor. We find that the motor dynamics can be characterized by two timescales: the moving-time interval for the mechanical rotation of the rotor and the waiting-time interval determined by the chemical transitions of the stators. We show that these two timescales depend differently on the load, and that their cross-over provides the microscopic explanation for the existence of two regimes in the torque-speed curves observed experimentally. We also analyze the speed fluctuation for a single motor by using our model. We show that the motion is smoothed by having more stator units. However, the mechanism for such fluctuation reduction is different depending on the load. We predict that the speed fluctuation is determined by the number of steps per revolution only at low load and is controlled by external noise for high load. Our model can be generalized to study other molecular motor systems with multiple power-generating units.
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