ArticleThe Plant cell2009
Zea mays annexins modulate cytosolic free Ca2+ and generate a Ca2+-permeable conductance.
Article in The Plant cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 151 citations in OpenAlex.
- Linking redox and calcium signaling via thioredoxins.Journal of experimental botany · 2026Review
- Peanut annexin AhANN6 promotes heat resistance in plant and bacterial cells.Plant molecular biology · 2025Article
- Function and evolution of plant annexins in response to abiotic stresses.BMC plant biology · 2025Review
- Augmenting riceProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Annexin-Membrane Interactions Across Eukaryotic Domains of Life-A Comparative Approach.International journal of molecular sciences · 2025Review
- Annexins: central regulators of plant growth and stress signaling.Acta biochimica et biophysica Sinica · 2025Review
- The Wheat AnnexinInternational journal of molecular sciences · 2023Article
- Role of Actin Dynamics andGenes · 2023Review
- UPL5 modulates WHY2 protein distribution in a Kub-site dependent ubiquitination in response to [CaiScience · 2023Article
- ATANN3 Is Involved in Extracellular ATP-Regulated Auxin Distribution inPlants (Basel, Switzerland) · 2023Article
- GmWAK1, Novel Wall-Associated Protein Kinase, Positively Regulates Response of Soybean toInternational journal of molecular sciences · 2023Article
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- Genome-Wide Characterization and Abiotic Stresses Expression Analysis of Annexin Family Genes in Poplar.International journal of molecular sciences · 2022Article
- Delineating Calcium Signaling Machinery in Plants: Tapping the Potential through Functional Genomics.Current genomics · 2021Review
- Calmodulin and Its Interactive Proteins Participate in Regulating the Explosive Growth ofInternational journal of molecular sciences · 2021Article
- Ectomycorrhizal Fungal Strains Facilitate CdInternational journal of molecular sciences · 2021Article
- Categorization of Orthologous Gene Clusters in 92 Ascomycota Genomes Reveals Functions Important for Phytopathogenicity.Journal of fungi (Basel, Switzerland) · 2021Article
- The calcium transporter ANNEXIN1 mediates cold-induced calcium signaling and freezing tolerance in plants.The EMBO journal · 2021Article
- A MIF-like effector suppresses plant immunity and facilitates nematode parasitism by interacting with plant annexins.Journal of experimental botany · 2019Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Regulation of reactive oxygen species and cytosolic free calcium ([Ca(2+)](cyt)) is central to plant function. Annexins are small proteins capable of Ca(2+)-dependent membrane binding or membrane insertion. They possess structural motifs that could support both peroxidase activity and calcium transport. Here, a Zea mays annexin preparation caused increases in [Ca(2+)](cyt) when added to protoplasts of Arabidopsis thaliana roots expressing aequorin. The pharmacological profile was consistent with annexin activation (at the extracellular plasma membrane face) of Arabidopsis Ca(2+)-permeable nonselective cation channels. Secreted annexins could therefore modulate Ca(2+) influx. As maize annexins occur in the cytosol and plasma membrane, they were incorporated at the intracellular face of lipid bilayers designed to mimic the plasma membrane. Here, they generated an instantaneously activating Ca(2+)-permeable conductance at mildly acidic pH that was sensitive to verapamil and Gd(3+) and had a Ca(2+)-to-K(+) permeability ratio of 0.36. These results suggest that cytosolic annexins create a Ca(2+) influx pathway directly, particularly during stress responses involving acidosis. A maize annexin preparation also demonstrated in vitro peroxidase activity that appeared independent of heme association. In conclusion, this study has demonstrated that plant annexins create Ca(2+)-permeable transport pathways, regulate [Ca(2+)](cyt), and may function as peroxidases in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.