ArticleApplied and environmental microbiology2009
Dogs are a reservoir of ampicillin-resistant Enterococcus faecium lineages associated with human infections.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Transmission routes of antibiotic resistant bacteria: a systematic review.BMC infectious diseases · 2022Pooled it
- Systematic Review and Meta-Analysis of the Occurrence of ESKAPE Bacteria Group in Dogs, and the Related Zoonotic Risk in Animal-Assisted Therapy, and in Animal-Assisted Activity in the Health Context.International journal of environmental research and public health · 2020Pooled it
- Draft genome sequencing of anMicrobiology resource announcements · 2026Article
- Enrofloxacin, Effective Treatment ofMicroorganisms · 2024Article
- An Epidemiologic Study of Bacterial Culture and Antibiotic Susceptibility Analyses in Captive Macaques and Marmosets at the Wisconsin National Primate Research Center.Journal of the American Association for Laboratory Animal Science : JAALAS · 2024Article
- Antimicrobial Resistance Profiles ofMicroorganisms · 2023Article
- Virulence genes and antimicrobial resistance in Enterococcus strains isolated from dogs and cats in Northeast China.The Journal of veterinary medical science · 2023Article
- Antibiotic Resistance and Species Profile ofVeterinary sciences · 2022Article
- Effect of antimicrobial administration on fecal microbiota of critically ill dogs: dynamics of antimicrobial resistance over time.Animal microbiome · 2022Article
- Consumer attitudes toward bacteriophage applications to pet food.Frontiers in veterinary science · 2022Article
- Evaluation of a Biocide Used in the Biological Isolation and Containment Unit of a Veterinary Teaching Hospital.Antibiotics (Basel, Switzerland) · 2021Article
- Bacteriocins from Lactic Acid Bacteria. A Powerful Alternative as Antimicrobials, Probiotics, and Immunomodulators in Veterinary Medicine.Animals : an open access journal from MDPI · 2021Review
- One Health in hospitals: how understanding the dynamics of people, animals, and the hospital built-environment can be used to better inform interventions for antimicrobial-resistant gram-positive infections.Antimicrobial resistance and infection control · 2020Review
- Prevalence and Predictors of Antimicrobial Resistance AmongFrontiers in veterinary science · 2020Article
- A human-food web-animal interface on the prevalence of food-borne pathogens (Clostridia and Enterococcus) in mixed veterinary farms.Food science and biotechnology · 2019Article
- Evidence of Sharing of Klebsiella pneumoniae Strains between Healthy Companion Animals and Cohabiting Humans.Journal of clinical microbiology · 2019Article
- Complexities in understanding antimicrobial resistance across domesticated animal, human, and environmental systems.Annals of the New York Academy of Sciences · 2019Review
- Antimicrobial Resistance inMicrobiology spectrum · 2018Review
- Increase in antimicrobial resistance and emergence of major international high-risk clonal lineages in dogs and cats with urinary tract infection: 16 year retrospective study.The Journal of antimicrobial chemotherapy · 2018Article
- Safety assessment of commensal enterococci from dogs.Folia microbiologica · 2017Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ampicillin resistance is a marker for hospital-associated Enterococcus faecium. Feces from 208 dogs were selectively screened for the occurrence of ampicillin-resistant E. faecium (AREF). AREF was detected in 42 (23%) of 183 dogs screened in a cross-sectional study in the United Kingdom and in 19 (76%) of 25 dogs studied longitudinally in Denmark. AREF carriage was intermittent in all dogs studied longitudinally. Multilocus sequence typing of 63 canine AREF isolates revealed the presence of 13 distinct sequence types. Approximately 76% of the isolates belonged to hospital-adapted clonal complex 17 (CC17), including those of sequence types ST-78 and ST-192, which are widespread in European and Asian hospitals. Longitudinal screening of 18 healthy humans living in contact with 13 of the dogs under study resulted in the identification of a single, intermittent CC17 carrier. This person carried one of the sequence types (ST-78) recovered from his dog. Based on PCR and Southern hybridization analyses, the putative virulence gene cluster from orf903 to orf907 was widespread in canine AREF isolates (present in 97%), whereas orf2351 (present in 26% of isolates) and orf2430 (present in 31%) were strongly associated with CC17-related sequence types (P<0.05). Surprisingly, esp and hyl were not detected in any of the isolates. The antimicrobial resistance profiles of canine AREF isolates generally differed from those previously described for clinical human isolates. The results indicate that dogs are frequent carriers of CC17-related lineages and may play a role in the spread of this nosocomial pathogen. The distinctive virulence and antimicrobial resistance profiles observed among canine AREF isolates raise interesting questions about the origin and evolution of the strains causing human infections.
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