ArticleEvidence-based complementary and alternative medicine : eCAM2011
Garlic increases antioxidant levels in diabetic and hypertensive rats determined by a modified peroxidase method.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 89 citations in OpenAlex.
- Modulation of gene expression by traditional Asian antidiabetic nutraceuticals: A review of potential effects.Asia Pacific journal of clinical nutrition · 2025Review
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- Medicinal plants administered to control hypertension in Ethiopia: ethnomedicine, pharmacology, nutraceutical, phytochemistry, toxicology, and policy perspectives.Frontiers in cardiovascular medicine · 2025Review
- A Comprehensive Review of Moroccan Medicinal Plants for Diabetes Management.Diseases (Basel, Switzerland) · 2024Review
- Antidiabetic and Anti-Inflammatory Effect ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Onion anthocyanins: Extraction, stability, bioavailability, dietary effect, and health implications.Frontiers in nutrition · 2022Review
- Diallyl Trisulfide, the Antifungal Component of Garlic Essential Oil and the Bioactivity of Its Nanoemulsions Formed by Spontaneous Emulsification.Molecules (Basel, Switzerland) · 2021Article
- Impacts of garlic extract on testicular oxidative stress and sperm characteristics in type 1 and 2 diabetic rats: An experimental study.International journal of reproductive biomedicine · 2021Article
- The Anxiolytic and Antidepressant Effects of Diallyl Disulfide and GYY4137 in Animals with Chronic Neuropathic Pain.Antioxidants (Basel, Switzerland) · 2021Article
- Plants Used as Antihypertensive.Natural products and bioprospecting · 2021Review
- Effects ofFrontiers in pharmacology · 2021Review
- Chemical Constituents and Pharmacological Activities of Garlic (Nutrients · 2020Review
- Onion (Journal of food science and technology · 2019Article
- Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice.Scientific reports · 2018Article
- Natural antioxidants in the treatment and prevention of diabetic nephropathy; a potential approach that warrants clinical trials.Redox report : communications in free radical research · 2017Review
- Anti-diabetic and anti-oxidant potential of aged garlic extract (AGE) in streptozotocin-induced diabetic rats.BMC complementary and alternative medicine · 2016Article
- Garlic Attenuates Plasma and Kidney ACE-1 and AngII Modulations in Early Streptozotocin-Induced Diabetic Rats: Renal Clearance and Blood Pressure Implications.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Effect of Cinnamomum zeylanicumon on Spermatogenesis.Iranian Red Crescent medical journal · 2015Article
- Ancient records and modern research on the mechanisms of chinese herbal medicines in the treatment of diabetes mellitus.Evidence-based complementary and alternative medicine : eCAM · 2015Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative damage by free radicals has been implicated in the pathogenesis of vascular disease in diabetes and hypertension. In the present study, the total antioxidant status in diabetic and hypertensive rats before and after treatment with garlic (Allium sativum) was determined. The total serum antioxidants were measured by a modified method reported earlier by Miller and coworkers. The reproducibility of the assay was confirmed by determining standard curves for the known antioxidants: trolox (a stable analog of vitamin E), glutathione and vitamin C with interassay correlation coefficients (R(2), n = 10 in triplicate) of 0.9984, 0.9768 and 0.987, respectively, confirming the reliability and reproducibility of the assay. This assay was then used to determine total serum antioxidant levels of streptozotocin-induced diabetic rats and two-kidney one-clip hypertensive rats both before and after 3 weeks of treatment with an aqueous extract of garlic (500 mg/kg IP daily). The serum antioxidant levels of rats after 3 weeks of treatment were significantly higher (P < .001) than the pretreatment levels in both diabetic and hypertensive rats. The increased serum antioxidant levels were paralleled by a decrease in serum glucose in the garlic-treated diabetic rats and lowered systolic blood pressure in the garlic-treated hypertensive rats. We conclude from our study that (i) total antioxidants can be measured by a simple, reproducible, reliable assay and (ii) the total antioxidant status can be significantly improved by treatment with garlic.
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Registered trials
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