Trial reportJournal of feline medicine and surgery2009
Analgesic efficacy of perioperative use of vedaprofen, tramadol or their combination in cats undergoing ovariohysterectomy.
Trial report in Journal of feline medicine and surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Systematic review of the behavioural assessment of pain in cats.Journal of feline medicine and surgery · 2016Pooled it
- 2015 AAHA/AAFP pain management guidelines for dogs and cats.Journal of feline medicine and surgery · 2015Guideline
- Postoperative pain and short-term complications after two elective sterilization techniques: ovariohysterectomy or ovariectomy in cats.BMC veterinary research · 2018Trial
- Robenacoxib versus meloxicam for the control of peri-operative pain and inflammation associated with orthopaedic surgery in cats: a randomised clinical trial.BMC veterinary research · 2015Trial
- Comparison of preoperative tramadol and pethidine on postoperative pain in cats undergoing ovariohysterectomy.BMC veterinary research · 2014Trial
- Subcutaneous administration of tramadol after elective surgery is as effective as intravenous administration in relieving acute pain and inflammation in dogs.TheScientificWorldJournal · 2012Trial
- Opioid use and perioperative pain management practices in dogs and cats in Latvia: A national survey highlighting regional disparities and generational differences.Veterinary world · 2026Article
- Retrospective Evaluation of Anesthetic-Analgesic Protocols in Cats with and Without Transient Myocardial Thickening Following Gonadectomy.Animals : an open access journal from MDPI · 2026Article
- Lack of Effectiveness of Tramadol for Earlier Limb Weight-Bearing After Femoral Head and Neck Excision in 38 Dogs.Animals : an open access journal from MDPI · 2026Article
- Analgesic efficacy of oral tramadol-dipyrone combination in cats undergoing ovariohysterectomy.Frontiers in veterinary science · 2026Article
- Characterization of pain behaviors in kittens following ovariohysterectomy using video assessment.Scientific reports · 2025Article
- Intraoperative Isoflurane End-Tidal Concentration during Infusion of Fentanyl, Tramadol, or Fentanyl-Tramadol Combination in Cats.Veterinary sciences · 2024Article
- Evaluation of the analgesic efficacy of grapiprant compared with robenacoxib in cats undergoing elective ovariohysterectomy in a prospective, randomized, masked, non-inferiority clinical trial.Journal of feline medicine and surgery · 2024Article
- Comparison of analgesic efficacy of tramadol, morphine and methadone in cats undergoing ovariohysterectomy.Journal of feline medicine and surgery · 2024Article
- Intraoperative and early postoperative pain in cats that underwent ovariohysterectomy using a spay hook: a randomised, masked, experimental study.BMC veterinary research · 2023Article
- Review
- Randomised clinical trial comparing the perioperative analgesic efficacy of oral tramadol and intramuscular tramadol in cats.Journal of feline medicine and surgery · 2022Article
- Perioperative changes in cardiac biomarkers in juvenile cats during neutering.Frontiers in veterinary science · 2022Article
- 2022 ISFM Consensus Guidelines on the Management of Acute Pain in Cats.Journal of feline medicine and surgery · 2022Article
- Analgesic efficacy of laser acupuncture and electroacupuncture in cats undergoing ovariohysterectomy.The Journal of veterinary medical science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The analgesic efficacy of tramadol and/or vedaprofen was evaluated in cats submitted for elective ovariohysterectomy, using a randomised double blind placebo controlled design. Forty adult female cats (3.0+/-0.32kg; 1.8+/-0.7 years) were distributed into four groups. Vedaprofen PO (0.5mg/kg), tramadol SC (2mg/kg), both, or placebo was administered 1h before surgery and every 24 and 8h, respectively, for 72h after surgery. Pain score evaluated by interactive visual analogue and composite pain score and hyperalgesia by the von Frey filament test were recorded at 1, 2, 4, 6, 8, 12, 24, 28, 32, 48, 52, 56, 72, 96h and on the 7th day after surgery. Animals treated with combined vedaprofen and tramadol treatment did not need rescue analgesia, did not develop hyperalgesia, and their serum cortisol concentrations and pain scores were lower than placebo until 24 and 72h after surgery, respectively. Combined vedaprofen and tramadol treatment provided more effective postoperative analgesia and prevented hyperalgesia than when used on their own. Multimodal technique is a superior method of treating pain after feline ovariohysterectomy. This work also provides evidence for the benefits of analgesia for up to 3 days following ovariohysterectomy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.