ArticleNeuroImage2009
Characterization of white matter degeneration in elderly subjects by magnetic resonance diffusion and FLAIR imaging correlation.
Article in NeuroImage, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Trial
- Brain aging mechanisms with mechanical manifestations.Mechanisms of ageing and development · 2021Review
- Assessment of White Matter Integrity after Pediatric Traumatic Brain Injury.Journal of neurotrauma · 2020Article
- White Matter Regions With Low Microstructure in Young Adults Spatially Coincide With White Matter Hyperintensities in Older Adults.Frontiers in aging neuroscience · 2019Article
- Contribution of diffusion, perfusion and functional MRI to the disconnection hypothesis in subcortical vascular cognitive impairment.Stroke and vascular neurology · 2018Article
- Ventricular and Periventricular Anomalies in the Aging and Cognitively Impaired Brain.Frontiers in aging neuroscience · 2017Article
- Vascular factors and multiple measures of early brain health: CARDIA brain MRI study.PloS one · 2015Article
- Age-Related Modifications of Diffusion Tensor Imaging Parameters and White Matter Hyperintensities as Inter-Dependent Processes.Frontiers in aging neuroscience · 2015Article
- Improved DTI registration allows voxel-based analysis that outperforms tract-based spatial statistics.NeuroImage · 2014Article
- Article
- Article
- Advanced BrainAGE in older adults with type 2 diabetes mellitus.Frontiers in aging neuroscience · 2013Article
- Age-related decline in white matter tract integrity and cognitive performance: a DTI tractography and structural equation modeling study.Neurobiology of aging · 2012Article
- White matter hyperintensity penumbra.Stroke · 2011Article
- Joint assessment of structural, perfusion, and diffusion MRI in Alzheimer's disease and frontotemporal dementia.International journal of Alzheimer's disease · 2011Article
- Quantifying the effects of normal ageing on white matter structure using unsupervised tract shape modelling.NeuroImage · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Fluid attenuated inversion recovery (FLAIR) and diffusion tensor imaging (DTI) techniques have been widely used to evaluate white matter (WM) alterations associated with aging, dementia and cerebral vascular disease. The relationship between FLAIR detected WM lesions (WML) and DTI detected WM integrity changes, however, remains unclear. To investigate this association, voxelwise correlations between 4 Tesla DTI and FLAIR images from elderly subjects were performed by relating WML volume and intensity in FLAIR to fractional anisotropy (FA) and mean diffusivity (MD) in DTI. Significant DTI-FLAIR correlations were found in regions overlapping with the WML of moderate intensities in FLAIR. No significant correlations were detected in periventricular regions where the FLAIR intensities are particularly high. The findings are consistent with a transitional model for WM degeneration from normal WM to cerebrospinal fluid (CSF). The results show that the correlation between DTI and FLAIR disappears when the FLAIR intensity of WML reaches its maximum at a certain lesion severity, and that the correlations may remerge with reversed signs when the lesion severity is further increased. These results suggest that the different stages of WM degeneration in elderly subjects can be better characterized by regional DTI-FLAIR correlations than single modality alone.
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Registered trials
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