ArticleBiochemical and biophysical research communications2009
Adapting collagen/CNT matrix in directing hESC differentiation.
Article in Biochemical and biophysical research communications, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of nanomaterials on embryonic stem cell neural differentiation: a systematic review.European journal of medical research · 2023Pooled it
- Beyond Reinforcement: Collagen-Inorganic Composites as a Roadmap for Next-Generation Biomaterials.ACS materials Au · 2026Review
- Regenerative Medicine and Nanotechnology Approaches against Cardiovascular Diseases: Recent Advances and Future Prospective.Current stem cell research & therapy · 2025Review
- The role of collagen and collagen I/III ratio in pathological conditions: insights into molecular mechanisms and therapeutic approaches.Frontiers in bioengineering and biotechnology · 2025Review
- Micro/nanoengineered technologies for human pluripotent stem cells maintenance and differentiation.Nano today · 2021Article
- Aligned Collagen-CNT Nanofibrils and the Modulation Effect on Ovarian Cancer Cells.Journal of composites science · 2021Article
- The Materiobiology of Silk: Exploring the Biophysical Influence of Silk Biomaterials on Directing Cellular Behaviors.Frontiers in bioengineering and biotechnology · 2021Review
- The Story of Nanoparticles in Differentiation of Stem Cells into Neural Cells.Neurochemical research · 2019Review
- Culture of dental pulp stem cells on nanoporous alumina substrates modified by carbon nanotubes.International journal of nanomedicine · 2019Article
- Silk-CNT Mediated Fibroblast Stimulation toward Chronic Wound Repair.Recent progress in materials · 2019Article
- The Role of Biomaterials in Implantation for Central Nervous System Injury.Cell transplantation · 2018Review
- Optimization of Glutaraldehyde Vapor Treatment for Electrospun Collagen/Silk Tissue Engineering Scaffolds.ACS omega · 2017Article
- Functionalized carbon nanotubes as suitable scaffold materials for proliferation and differentiation of canine mesenchymal stem cells.International journal of nanomedicine · 2017Article
- Time dependency of morphological remodeling of endothelial cells in response to substrate stiffness.BioImpacts : BI · 2017Article
- Guiding osteogenesis of mesenchymal stem cells using carbon-based nanomaterials.Nano convergence · 2017Review
- The nanomaterial toolkit for neuroengineering.Nano convergence · 2016Review
- Effect of CNT on collagen fiber structure, stiffness assembly kinetics and stem cell differentiation.Materials science & engineering. C, Materials for biological applications · 2015Article
- E-spun composite fibers of collagen and dragline silk protein: fiber mechanics, biocompatibility, and application in stem cell differentiation.Biomacromolecules · 2015Article
- Collagen gel formation in the presence of a carbon nanobrush.Journal of materials science. Materials in medicine · 2015Article
- Behaviors of stem cells on carbon nanotube.Biomaterials research · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The lineage selection in human embryonic stem cell (hESC) differentiation relies on both the growth factors and small molecules in the media and the physical characteristics of the micro-environment. In this work, we utilized various materials, including the collagen-carbon nanotube (collagen/CNT) composite material, as cell culture matrices to examine the impact of matrix properties on hESC differentiation. Our AFM analysis indicated that the collagen/CNT formed rigid fibril bundles, which polarized the growth and differentiation of hESCs, resulting in more than 90% of the cells to the ectodermal lineage in Day 3 in the media commonly used for spontaneous differentiation. We also observed the differentiated cells followed the coarse alignment of the collagen/CNT matrix. The research not only revealed the responsiveness of hESCs to matrix properties, but also provided a simple yet efficient way to direct the hESC differentiation, and imposed the potential of forming neural-cell based bio-devices for further applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.