ArticleHearing research2009
Transient gain adjustment in the inferior colliculus is serotonin- and calcium-dependent.
Article in Hearing research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Distribution of Metabotropic Serotonin Receptors in GABAergic and Glutamatergic Neurons in the Auditory Midbrain.The Journal of comparative neurology · 2026Article
- L-type calcium channel modulation reveals the relationship between neuronal synchrony and hyperactivity in the inferior colliculus following noise-induced hearing loss.Scientific reports · 2025Article
- Neural Correlates of Perceptual Plasticity in the Auditory Midbrain and Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural correlates of flexible sound perception in the auditory midbrain and thalamus.bioRxiv : the preprint server for biology · 2024Article
- Silence, Solitude, and Serotonin: Neural Mechanisms Linking Hearing Loss and Social Isolation.Brain sciences · 2020Review
- Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System.HSOA trends in anatomy and physiology · 2018Article
- Age-related changes in envelope-following responses at equalized peripheral or central activation.Neurobiology of aging · 2017Article
- Age-Related Changes in Processing Simultaneous Amplitude Modulated Sounds Assessed Using Envelope Following Responses.Journal of the Association for Research in Otolaryngology : JARO · 2016Article
- Metabotropic glutamate receptors in auditory processing.Neuroscience · 2014Review
- Age-related changes in the relationship between auditory brainstem responses and envelope-following responses.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Dissociated neurons and glial cells derived from rat inferior colliculi after digestion with papain.PloS one · 2013Article
- From behavioral context to receptors: serotonergic modulatory pathways in the IC.Frontiers in neural circuits · 2012Article
- Context-dependent modulation of auditory processing by serotonin.Hearing research · 2011Review
- Cholinergic cells of the pontomesencephalic tegmentum: connections with auditory structures from cochlear nucleus to cortex.Hearing research · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the inferior colliculus (IC), a brief period of acoustic conditioning can transiently enhance evoked discharge rate. The cellular basis of this phenomenon was assessed with whole cell current-clamp recordings in a gerbil IC brain slice preparation. The current needed to elicit a single action potential was first established for each neuron. A 5s synaptic stimulus train was delivered to the lateral lemniscus (LL), and followed immediately by the initial current pulse to assess a change in postsynaptic gain. The majority of IC neurons (66%) displayed an increase in current-evoked action potentials (Positive Gain). Despite the blockade of ionotropic glutamate receptors, this effect was correlated with membrane depolarization that occurred during the synaptic train. The postsynaptic mechanism for positive gain was examined by selective blockade of specific neurotransmitter receptors. Gain in action potentials was enhanced by antagonists of metabotropic glutamate, acetylcholine, GABA(A) and glycine receptors. In contrast, the gain was blocked or reduced by an antagonist to ionotropic serotonin receptors (5-HT(3)R). Blocking voltage-activated calcium channels with verapamil also reduced the effect. These results suggest that 5-HT(3)R activation, coupled with increased intracellular calcium, can transiently alter postsynaptic excitability in IC neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.