ArticleCytokine2009
Developmental changes in circulating IL-8/CXCL8 isoforms in neonates.
Article in Cytokine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Osteoid cell-derived chemokines drive bone-metastatic prostate cancer.Frontiers in oncology · 2023Review
- Cytokines in Inflammatory Disease.International journal of molecular sciences · 2019Review
- Colonization of preterm gnotobiotic piglets with probiotic Lactobacillus rhamnosus GG and its interference with Salmonella Typhimurium.Clinical and experimental immunology · 2019Article
- Gestational Hypoxia and Developmental Plasticity.Physiological reviews · 2018Review
- An Immunological Perspective on Neonatal Sepsis.Trends in molecular medicine · 2016Review
- Article
- A model of neurodevelopmental risk and protection for preterm infants.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2013Article
- Preterm human milk contains a large pool of latent TGF-β, which can be activated by exogenous neuraminidase.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine.Gastroenterology · 2011Article
- Extracorporeal membrane oxygenation causes loss of intestinal epithelial barrier in the newborn piglet.Pediatric research · 2010Article
- Epithelial cells in fetal intestine produce chemerin to recruit macrophages.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- The Phylogeny, Ontogeny, and Organ-specific Differentiation of Macrophages in the Developing Intestine.Newborn (Clarksville, Md.)Article
- A model of neurodevelopmental risk and protection for preterm infants.The Journal of perinatal & neonatal nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Interleukin-8 (IL-8/CXCL8) is widely expressed in fetal tissues although inflammatory changes are not seen. Circulating IL-8 is comprised of an endothelial-derived [ala-IL-8](77) isoform and another, more potent [ser-IL-8](72) secreted by most other cells; [ala-IL-8](77) can be converted into [ser-IL-8](72) by proteolytic removal of an N-terminal pentapeptide from [ala-IL-8](77). In this study, we show [ala-IL-8](77) is the predominant circulating isoform of IL-8 in premature neonates but not in term neonates/adults, who have [ser-IL-8](72) as the major isoform. This isoform switch from the less potent [ala-IL-8](77) to [ser-IL-8](72) correlates with a maturational increase in the neutrophil chemotactic potency of plasma IL-8. The emergence of [ser-IL-8](72) as the major isoform is likely due to increased plasma [ala-IL-8](77)-convertase activity and/or changes in the cellular sources of IL-8. Developmental changes in IL-8 isoforms may serve to minimize its inflammatory effects in the fetus and also provide a mechanism to restore its full activity after birth.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.