ArticleBiochimica et biophysica acta2009
Over-expression of the transcription factor, ZBP-89, leads to enhancement of the C2C12 myogenic program.
Article in Biochimica et biophysica acta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Effects of mineral methionine hydroxy analog chelate in sow diets on epigenetic modification and growth of progeny.Journal of animal science · 2020Article
- Gene loci associated with insulin secretion in islets from non-diabetic mice.The Journal of clinical investigation · 2019Article
- Klf4, Klf2, and Zfp148 activate autophagy-related genes in smooth muscle cells during aortic aneurysm formation.Physiological reports · 2019Article
- ZFP148 (Zinc-Finger Protein 148) Binds Cooperatively With NF-1 (Neurofibromin 1) to Inhibit Smooth Muscle Marker Gene Expression During Abdominal Aortic Aneurysm Formation.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Damage to the myogenic differentiation of C2C12 cells by heat stress is associated with up-regulation of several selenoproteins.Scientific reports · 2018Article
- Transcription factor ZNF148 is a negative regulator of human muscle differentiation.Scientific reports · 2017Article
- Oncorhynchus mykiss pax7 sequence variations with comparative analyses against other teleost species.SpringerPlus · 2015Article
- MicroRNA-203 enhances coxsackievirus B3 replication through targeting zinc finger protein-148.Cellular and molecular life sciences : CMLS · 2013Article
- Overexpression of Six1 leads to retardation of myogenic differentiation in C2C12 myoblasts.Molecular biology reports · 2013Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Myogenesis involves the complex interplay between the down-regulation of non-muscle genes and the up-regulation of muscle-specific genes. This interplay is controlled by the myogenic regulatory factors Myf5, MRF4, MyoD and myogenin. To trigger the up-regulation of these muscle-specific factors, certain environmental cues, such as the removal of serum, signal C2C12 myoblast cells to withdraw from cell cycle, fuse and activate muscle-specific genes. Here, the level of ZBP-89 (zfp148), a Krüppel-like transcription factor, has been shown to increase during myogenesis. Over-expression of ZBP-89, via adenoviral infection, led to the enhancement of the myogenic program without requiring the removal of serum. Quantitative real-time PCR and ChIP assays documented that ZBP-89 promoted the down-regulation of Pax7 coupled with the up-regulation of MRF4 and MyoD to regulate C2C12 differentiation in vitro. In addition, ZBP-89 over-expression up-regulated p21 and Rb while promoting the down-regulation of cyclinA and cyclinD1. In converse, the diminution of ZBP-89 by siRNA promoted the retention of myogenic and cell cycle regulators at myoblast levels resulting in a concomitant delay of the myogenic program. From these studies we conclude that the transcription factor ZBP-89 plays an important role in the timing of the myogenic program.
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