ReviewArthritis research & therapy2009
Developments in the scientific and clinical understanding of the spondyloarthritides.
Review in Arthritis research & therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- 18F-fluoride PET/CT for detection of sacroiliitis in ankylosing spondylitis.European journal of nuclear medicine and molecular imaging · 2010Trial
- The relationship of serum endocan levels and anti-TNF-alpha therapy in patients with ankylosing spondylitis.European journal of rheumatology · 2018Article
- Anti-tumor necrosis factor drug survival in axial spondyloarthritis is independent of the classification criteria.Rheumatology international · 2015Observational
- Involvement of IL-23 in enteropathic arthritis patients with inflammatory bowel disease: preliminary results.Clinical rheumatology · 2014Article
- Drug retention rates and treatment discontinuation among anti-TNF-α agents in psoriatic arthritis and ankylosing spondylitis in clinical practice.Mediators of inflammation · 2014Article
- Lipopolysaccharide treatment suppresses spontaneously developing ankylosing enthesopathy in B10.BR male mice: the potential role of interleukin-10.BMC musculoskeletal disorders · 2012Article
- Classification criteria for spondyloarthropathies.World journal of orthopedics · 2011Article
- Early NGF-TrkA-CGRP signaling-related changes in dorsal root ganglia are associated with mechanical hypersensitivity in a zymosan A-induced SKG model prior to overt arthritis.Neurobiology of pain (Cambridge, Mass.)Article
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Authors and funding
1 author.
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Abstract
Major advances have been achieved over the last 10 years both in the clinical and scientific understanding of the spondyloarthritides (SpA), which can be separated in predominantly axial and predominantly peripheral SpA. The clinical progress includes the development of classification criteria, strategies for early diagnosis, definition of outcome criteria for clinical studies, and the conduction of a series of clinical studies with a focus on tumor necrosis factor (TNF) blockers. The proven high efficacy of TNF blocker treatment has meant a breakthrough for SpA patients, who until recently had only quite limited treatment options. More and more data have accumulated over recent years in regard to long-term efficacy and safety, prediction of response, and the relevance of extrarheumatic manifestations such as uveitis, psoriasis, and inflammatory bowel disease for treatment decisions with TNF blockers. A better understanding of the interaction of the immune system and inflammation with bone degradation/new bone formation is crucial for the development of optimal treatment strategies to prevent structural damage. Recent results from genetic studies could show that, besides HLA-B27, the interleukin-23 receptor and the ARTS1 enzyme are associated with ankylosing spondylitis. Only when the exact pathogenesis is clarified will a curative treatment be possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.