ArticleEuropean journal of drug metabolism and pharmacokinetics
Diclofenac and ketoprofen liver toxicity in rat.
Article in European journal of drug metabolism and pharmacokinetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 54 citations in OpenAlex.
- Potential acute hepatic injury in 2 cats exposed to topical human diclofenac.The Canadian veterinary journal = La revue veterinaire canadienne · 2026Article
- From Chemistry to Pharmacology: Exploring the Anti-Inflammatory and Antioxidant Potential of Novel Dexketoprofen Amide Derivatives.Antioxidants (Basel, Switzerland) · 2025Article
- Recent advancement in prevention against hepatotoxicity, molecular mechanisms, and bioavailability of gallic acid, a natural phenolic compound: challenges and perspectives.Frontiers in pharmacology · 2025Review
- Hepatoprotective and nephroprotective effects ofVeterinary world · 2023Article
- Protective impacts ofToxicology research · 2023Article
- Carvacrol Exerts Anti-Inflammatory, Anti-Oxidative Stress and Hepatoprotective Effects Against Diclofenac-Induced Liver Injury in Male Rats.International journal of preventive medicine · 2023Article
- Article
- Safety Study on Ketoprofen in Pigs: Evaluating the Effects of Different Dosing and Treatment Scheme on Hematological, Hepatic, and Renal Parameters.Veterinary sciences · 2021Article
- Impacts of Color Coding on Programming Learning in Multimedia Learning: Moving Toward a Multimodal Methodology.Frontiers in psychology · 2021Article
- Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressingPharmaceutical biology · 2020Article
- Evaluation of histophysiological alterations associated with ketoprofen administration in albino NMRI mice.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Controlled and tuneable drug release from electrospun fibers and a non-invasive approach for cytotoxicity testing.Scientific reports · 2019Article
- Effects of NSAIDs on the Release of Calcitonin Gene-Related Peptide and Prostaglandin EMediators of inflammation · 2017Article
- Consumption of non-steroidal anti-inflammatory drugs in Serbia: a comparison with Croatia and Denmark during 2005-2008.European journal of clinical pharmacology · 2011Article
- Kolaviron Diminishes Diclofenac-Induced Liver and Kidney Toxicity in Wistar Rats Via Suppressing Inflammatory Events, Upregulating Antioxidant Defenses, and Improving Hematological Indices.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last years there appeared many articles about the adverse influence of non-steroidal anti-inflammatory drugs on the liver and heart. This study is concerned with the influence of the duration of treatment with diclofenac and ketoprofen on the macroscopic and microscopic changes in the liver, lungs, heart, and kidneys in rats. Experiments were carried out on mature Wistar strain rats. Animals of test groups received diclofenac and ketoprofen in a dose of 8 mg/kg/day (equivalent to the therapeutic dose for man) during 7 per os (p.o.) or 28 days intraperitoneally (i.p.), whereas controls received physiological solution p.o. A high morbidity was observed in the animals receiving diclofenac p.o. and somewhat lower in those treated with ketoprofen. On the other hand, the rats got through the 28-day i.p. treatment with both drugs mainly without significant complications. Macroscopic examinations revealed some changes in treated rats: distension of the stomach, ascites, fibrin deposits on the internal organs, lung effusion and the changes in color and structure of the liver. These changes were more frequent in the group of rats receiving diclofenac for the 7 days compared with those that received ketoprofen for the same time. It may be thought that the high mortality and macroscopic changes in the internal organs of experimental animals are a consequence of the microscopic changes in the liver and its lowered function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.