ArticleMuscle & nerve2009
Upregulation of MHC class I in transgenic mice results in reduced force-generating capacity in slow-twitch muscle.
Article in Muscle & nerve, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- (5R)-5-Hydroxytriptolide (LLDT-8) Ameliorates Experimental Autoimmune Myositis via Suppression of the NLRC5/MHC-I Signaling Pathway.Pharmaceuticals (Basel, Switzerland) · 2026Article
- The emerging roles of necroptosis in skeletal muscle health and disease.Pflugers Archiv : European journal of physiology · 2024Review
- Muscle fiber necroptosis in pathophysiology of idiopathic inflammatory myopathies and its potential as target of novel treatment strategy.Frontiers in immunology · 2023Review
- HMGB1 expression and muscle regeneration in idiopathic inflammatory myopathies and degenerative joint diseases.Journal of muscle research and cell motility · 2015Article
- Increased levels of HSPA5 in the serum of patients with inflammatory myopathies--preliminary findings.Clinical rheumatology · 2015Article
- Innate immune-response mechanisms in dermatomyositis: an update on pathogenesis, diagnosis and treatment.Drugs · 2014Review
- Isometric and eccentric force generation assessment of skeletal muscles isolated from murine models of muscular dystrophies.Journal of visualized experiments : JoVE · 2013Article
- Daily supplementation of D-ribose shows no therapeutic benefits in the MHC-I transgenic mouse model of inflammatory myositis.PloS one · 2013Article
- The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy.Arthritis and rheumatism · 2012Article
- Role of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies.Arthritis research & therapy · 2012Review
- Pathogenesis, classification and treatment of inflammatory myopathies.Nature reviews. Rheumatology · 2011Review
- A national registry for juvenile dermatomyositis and other paediatric idiopathic inflammatory myopathies: 10 years' experience; the Juvenile Dermatomyositis National (UK and Ireland) Cohort Biomarker Study and Repository for Idiopathic Inflammatory Myopathies.Rheumatology (Oxford, England) · 2011Article
- Juvenile dermatomyositis: new developments in pathogenesis, assessment and treatment.Best practice & research. Clinical rheumatology · 2009Review
- Developments in the scientific and clinical understanding of inflammatory myopathies.Arthritis research & therapy · 2008Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Expression of major histocompatibility complex (MHC) class I in skeletal muscle fibers is an early and consistent finding in inflammatory myopathies. To test if MHC class I has a primary role in muscle impairment, we used transgenic mice with inducible overexpression of MHC class I in their skeletal muscle cells. Contractile function was studied in isolated extensor digitorum longus (EDL, fast-twitch) and soleus (slow-twitch) muscles. We found that EDL was smaller, whereas soleus muscle was slightly larger. Both muscles generated less absolute force in myopathic compared with control mice; however, when force was expressed per cross-sectional area, only soleus muscle generated less force. Inflammation was markedly increased, but no changes were found in the activities of key mitochondrial and glycogenolytic enzymes in myopathic mice. The induction of MHC class I results in muscle atrophy and an intrinsic decrease in force-generation capacity. These observations may have important implications for our understanding of the pathophysiological processes of muscle weakness seen in inflammatory myopathies. Muscle Nerve, 2008.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.