ArticleJournal of computational neuroscience2009
Spine neck geometry determines spino-dendritic cross-talk in the presence of mobile endogenous calcium binding proteins.
Article in Journal of computational neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 57 citations in OpenAlex.
- α-MSH-catabolic enzyme prolylcarboxypeptidase in nucleus accumbens shell ameliorates stress susceptibility in mice through regulating synaptic plasticity.Acta pharmacologica Sinica · 2023Article
- Control of CaGlia · 2022Article
- Dendritic spine morphology regulates calcium-dependent synaptic weight change.The Journal of general physiology · 2022Article
- Stochastic reaction-diffusion modeling of calcium dynamics in 3D dendritic spines of Purkinje cells.Biophysical journal · 2021Article
- Is Purkinje Neuron Hyperpolarisation Important for Cerebellar Synaptic Plasticity? A Retrospective and Prospective Analysis.Cerebellum (London, England) · 2020Review
- Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat.Scientific reports · 2020Article
- The Origin of Physiological Local mGluR1 Supralinear CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium.The Journal of general physiology · 2019Article
- Disruption of Timing: NeuroHIV Progression in the Post-cART Era.Scientific reports · 2019Article
- HIV-1 proteins dysregulate motivational processes and dopamine circuitry.Scientific reports · 2018Article
- Cdk5 Is Essential for Amphetamine to Increase Dendritic Spine Density in Hippocampal Pyramidal Neurons.Frontiers in cellular neuroscience · 2017Article
- HIV-1 and cocaine disrupt dopamine reuptake and medium spiny neurons in female rat striatum.PloS one · 2017Article
- Extrusion versus diffusion: mechanisms for recovery from sodium loads in mouse CA1 pyramidal neurons.The Journal of physiology · 2016Article
- Enhanced Glutamatergic Synaptic Plasticity in the Hippocampal CA1 Field of Food-Restricted Rats: Involvement of CB1 Receptors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Location matters: somatic and dendritic SK channels answer to distinct calcium signals.Journal of neurophysiology · 2015Article
- Neuronal calcium signaling: function and dysfunction.Cellular and molecular life sciences : CMLS · 2014Review
- Paired-pulse facilitation at recurrent Purkinje neuron synapses is independent of calbindin and parvalbumin during high-frequency activation.The Journal of physiology · 2013Article
- Mechanisms of psychostimulant-induced structural plasticity.Cold Spring Harbor perspectives in medicine · 2012Article
- Functional integration of calcium regulatory mechanisms at Purkinje neuron synapses.Cerebellum (London, England) · 2012Review
- A stochastic signaling network mediates the probabilistic induction of cerebellar long-term depression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic spines are thought to compartmentalize second messengers like Ca2+. The notion of isolated spine signaling, however, was challenged by the recent finding that under certain conditions mobile endogenous Ca(2+)-binding proteins may break the spine limit and lead to activation of Ca(2+)-dependent dendritic signaling cascades. Since the size of spines is variable, the spine neck may be an important regulator of this spino-dendritic crosstalk. We tested this hypothesis by using an experimentally defined, kinetic computer model in which spines of Purkinje neurons were coupled to their parent dendrite by necks of variable geometry. We show that Ca2+ signaling and calmodulin activation in spines with long necks is essentially isolated from the dendrite, while stubby spines show a strong coupling with their dendrite, mediated particularly by calbindin D28k. We conclude that the spine neck geometry, in close interplay with mobile Ca(2+)-binding proteins, regulates the spino-dendritic crosstalk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.