Evidence map›Paper›PMID 19229577›Full record

ArticleSleep & breathing = Schlaf & Atmung2009

Cost-effectiveness of oral appliances in the treatment of obstructive sleep apnoea-hypopnoea.

Mohsen Sadatsafavi, Carlo A Marra, Najib T Ayas, John Stradling, John Fleetham

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06972823 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Assessing Changes in Oral Functions and Speech After Using 3D-Printed vs. Custom-made Mouth Guards in Children Practicing Contact Sports: A Randomized Clinical Trial

TypeinterventionalSponsorCairo UniversityRan2025 to 2026Enrolled60ConditionsMouthguard Use, Orofacial Injuries Prevention, 3D Printed Mouthguard, Traditional Custom-made MouthguardArms3D printed custom-made mouthguards, Traditional custom-made mouthguards
NCT07000435 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Assessing Thickness Changes Following the Use of 3D-Printed Vs. Custom-Made Mouth Guards to Prevent Traumatic Dental Injuries in Children Practicing Contact Sports: A Randomized Clinical Trial.

TypeinterventionalSponsorCairo UniversityRan2025 to 2026Enrolled56ConditionsMouthguard Use Orofacial Injuries Prevention 3D Printed Mouthguard Traditional Custom-made Mouthguard Occlusal Thickness ChangesArms3D printed custom-made mouth guards, Traditional custom-made mouth guards
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Clinical- and Cost-Effectiveness of a Mandibular Advancement Device Versus Continuous Positive Airway Pressure in Moderate Obstructive Sleep Apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019
    Trial
  4. Trial
  5. Trial
  6. Article
  7. Development of a physiological-based model that uses standard polysomnography and clinical data to predict oral appliance treatment outcomes in obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Article
  8. Article
  9. Development of a Sleep Apnea-Specific Health State Utility Algorithm.JAMA otolaryngology-- head & neck surgery · 2020
    Article
  10. Article
  11. Value within otolaryngology: Assessment of the cost-utility analysis literature.World journal of otorhinolaryngology - head and neck surgery · 2016
    Review
  12. Decision Modeling in Sleep Apnea: The Critical Roles of Pretest Probability, Cost of Untreated Obstructive Sleep Apnea, and Time Horizon.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016
    Article
  13. Article
  14. A Cost-Effectiveness Analysis of Surgery for Middle-Aged Men with Severe Obstructive Sleep Apnea Intolerant of CPAP.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015
    Article
  15. Sleep apnea and occupational accidents: Are oral appliances the solution?Indian journal of occupational and environmental medicine · 2014
    Review
  16. Comparison of adjustable and fixed oral appliances for the treatment of obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2011
    Article
  17. Article
  18. Treatment options for obstructive sleep apnea.Current treatment options in neurology · 2009
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Mohsen SadatsafaviCollaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, BC, Canada.
Carlo A Marra
Najib T Ayas
John Stradling
John Fleetham
Vancouver General Hospital · CASt. Paul's Hospital · CAUniversity of British Columbia · CAUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOral appliances (OA) are commonly prescribed for the treatment of obstructive sleep apnoea-hypopnoea (OSAH), but there is limited evidence on their cost-effectiveness. MATERIALS AND

methodsA model was designed to simulate the costs and benefits of treatment of OSAH with OA or continuous positive airway pressure (CPAP) based on their effects on quality of life, motor vehicle crashes, and cardiovascular effects. The primary outcome was the incremental cost-effectiveness ratio (ICER) in terms of costs per one quality-adjusted life year (QALY) gained 5 years after treatment.

resultsCompared with no treatment, OA results in $268 higher costs and an incremental QALY of 0.0899 per patient (ICER = $2,984/QALY). Compared with OA, CPAP resulted in $1,917 more costs and 0.0696 additional QALYs (ICER = $27,540/QALY). For the most part in the sensitivity analyses, CPAP remained cost-effective compared to OA, and OA remained cost-effective with respect to no treatment in almost all scenarios.

conclusionsOAs are less economically attractive than CPAP but remain a cost-effective treatment for patients who are unwilling or unable to adhere to CPAP therapy.

Indexed as

AdultContinuous Positive Airway PressureCost-Benefit AnalysisFemaleHumansMaleMiddle AgedOrthodontic Appliances, RemovablePrevalenceSeverity of Illness IndexSleep Apnea, ObstructiveSmokingStroke

Identifiers

PMID19229577
OpenAlexW1987418926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.