ReviewHistochemistry and cell biology2009
Degradation of excess peroxisomes in mammalian liver cells by autophagy and other mechanisms.
Review in Histochemistry and cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Pexophagy and Oxidative Stress: Focus on Peroxisomal Proteins and Reactive Oxygen Species (ROS) Signaling Pathways.Antioxidants (Basel, Switzerland) · 2025Review
- Selective protein degradation through chaperone‑mediated autophagy: Implications for cellular homeostasis and disease (Review).Molecular medicine reports · 2025Review
- Genome-Wide Association (GWAS) Applied to Carcass and Meat Traits of Nellore Cattle.Metabolites · 2023Article
- Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging.Antioxidants (Basel, Switzerland) · 2022Review
- Review
- Review
- Autophagy and organelle homeostasis in cancer.Developmental cell · 2021Review
- Hydroxynonenal causes Langerhans cell degeneration in the pancreas of Japanese macaque monkeys.PloS one · 2021Article
- Emerging Roles of Impaired Autophagy in Fatty Liver Disease and Hepatocellular Carcinoma.International journal of hepatology · 2021Review
- Mitophagy in the Pathogenesis of Liver Diseases.Cells · 2020Review
- The cell biology of the retinal pigment epithelium.Progress in retinal and eye research · 2020Review
- Pexophagy: A Model for Selective Autophagy.International journal of molecular sciences · 2020Review
- Diverse Functions of Autophagy in Liver Physiology and Liver Diseases.International journal of molecular sciences · 2019Review
- Autophagy in bone homeostasis and the onset of osteoporosis.Bone research · 2019Article
- Pexophagy in yeast and mammals: an update on mysteries.Histochemistry and cell biology · 2018Review
- Redox Regulation of Homeostasis and Proteostasis in Peroxisomes.Physiological reviews · 2018Review
- Peroxisomes proliferation and pharmacological stimulation of autophagy in rat liver: evidence to support that autophagy may remove the "older" peroxisomes.Molecular and cellular biochemistry · 2017Article
- Article
- Peroxisomes and Kidney Injury.Antioxidants & redox signaling · 2016Review
- Redox regulated peroxisome homeostasis.Redox biology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we discuss the mechanisms for the degradation of excess peroxisomes in mammalian hepatocytes which include (a) autophagy, (b) the action of peroxisomal Lon protease and (c) the membrane disrupting effect of 15-lipoxygenase. A recent study using Atg7 conditional-knock-out mice revealed that 70-80% of excess peroxisomes are degraded by the autophagic process. The remaining 20-30% of excess peroxisomes is most probably degraded by the action of peroxisomal Lon protease. Finally, a selective disruption of the peroxisomal membrane has been shown to be mediated by 15-lipoxygenase activity which is followed by diffusion of matrix proteins into the cytoplasm and cytoplasmic proteolysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.