ArticlePLoS computational biology2009
Identification of potential pathway mediation targets in Toll-like receptor signaling.
Article in PLoS computational biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Plant Growth-Promoting Bacteria of Soil: Designing of Consortia Beneficial for Crop Production.Microorganisms · 2023Review
- Towards a Systems Biology Approach to Understanding the Lichen Symbiosis: Opportunities and Challenges of Implementing Network Modelling.Frontiers in microbiology · 2021Review
- Investigating the deregulation of metabolic tasks via Minimum Network Enrichment Analysis (MiNEA) as applied to nonalcoholic fatty liver disease using mouse and human omics data.PLoS computational biology · 2019Article
- Innate immune memory and homeostasis may be conferred through crosstalk between the TLR3 and TLR7 pathways.Science signaling · 2016Article
- EGFR Signal-Network Reconstruction Demonstrates Metabolic Crosstalk in EMT.PLoS computational biology · 2016Article
- Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M.Nature communications · 2015Article
- Cell scale host-pathogen modeling: another branch in the evolution of constraint-based methods.Frontiers in microbiology · 2015Article
- Personalized medicine approaches for colon cancer driven by genomics and systems biology: OncoTrack.Biotechnology journal · 2014Review
- The Rpe65 rd12 allele exerts a semidominant negative effect on vision in mice.Investigative ophthalmology & visual science · 2014Article
- Constraint-based models predict metabolic and associated cellular functions.Nature reviews. Genetics · 2014Review
- Systems-level analysis of innate immunity.Annual review of immunology · 2014Review
- A comprehensive map of the influenza A virus replication cycle.BMC systems biology · 2013Article
- The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM properties.Glycoconjugate journal · 2013Review
- Applying systems biology methods to the study of human physiology in extreme environments.Extreme physiology & medicine · 2013Article
- Linking transcriptional changes over time in stimulated dendritic cells to identify gene networks activated during the innate immune response.PLoS computational biology · 2013Article
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- Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0.Nature protocols · 2011Article
- Proteomics and systems biology: current and future applications in the nutritional sciences.Advances in nutrition (Bethesda, Md.) · 2011Review
- Partially glycosylated dendrimers block MD-2 and prevent TLR4-MD-2-LPS complex mediated cytokine responses.PLoS computational biology · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Recent advances in reconstruction and analytical methods for signaling networks have spurred the development of large-scale models that incorporate fully functional and biologically relevant features. An extended reconstruction of the human Toll-like receptor signaling network is presented herein. This reconstruction contains an extensive complement of kinases, phosphatases, and other associated proteins that mediate the signaling cascade along with a delineation of their associated chemical reactions. A computational framework based on the methods of large-scale convex analysis was developed and applied to this network to characterize input-output relationships. The input-output relationships enabled significant modularization of the network into ten pathways. The analysis identified potential candidates for inhibitory mediation of TLR signaling with respect to their specificity and potency. Subsequently, we were able to identify eight novel inhibition targets through constraint-based modeling methods. The results of this study are expected to yield meaningful avenues for further research in the task of mediating the Toll-like receptor signaling network and its effects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.