ArticleThe EMBO journal2009
The transcription factor OsNAC4 is a key positive regulator of plant hypersensitive cell death.
Article in The EMBO journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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90 citing papers in PubMed, 194 citations in OpenAlex.
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- Divergent response associates with the differential amplitudes of immunity againstFrontiers in plant science · 2025Article
- Plant NAC transcription factors in the battle against pathogens.BMC plant biology · 2024Review
- Multiomic analyses reveal key sectors of jasmonate-mediated defense responses in rice.The Plant cell · 2024Article
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- Chloroplastic Sec14-like proteins modulate growth and phosphate deficiency responses in Arabidopsis and rice.Plant physiology · 2023Article
- CaREM1.4 interacts with CaRIN4 to regulateHorticulture research · 2023Article
- Cytological, transcriptome and miRNome temporal landscapes decode enhancement of rice grain size.BMC biology · 2023Article
- Review
- Phosphorylation of OsTGA5 by casein kinase II compromises its suppression of defense-related gene transcription in rice.The Plant cell · 2022Article
- Genome-wide analyses of the mung bean NAC gene family reveals orthologs, co-expression networking and expression profiling under abiotic and biotic stresses.BMC plant biology · 2022Article
- Unraveling Plant Cell Death duringMicroorganisms · 2022Review
- A Rice R2R3-Type MYB Transcription Factor OsFLP Positively Regulates Drought Stress Response via OsNAC.International journal of molecular sciences · 2022Article
- A Model to Incorporate the bHLH Transcription Factor OsIRO3 within the Rice Iron Homeostasis Regulatory Network.International journal of molecular sciences · 2022Article
- Overexpression ofFrontiers in plant science · 2022Article
- Genome-wide identification and comprehensive analyses ofFrontiers in plant science · 2022Article
- FERONIA-like receptor 1-mediated calcium ion homeostasis is involved in the immune response.Frontiers in plant science · 2022Article
30 more citing papers are in PubMed but not listed here.
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8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hypersensitive response (HR) is a common feature of plant immune responses and a type of programmed cell death. However, little is known about the induction mechanism of HR cell death. We report that overexpression of OsNAC4, which encodes a plant-specific transcription factor, leads to HR cell death accompanied by the loss of plasma membrane integrity, nuclear DNA fragmentation and typical morphological changes. In OsNAC4 knock-down lines, HR cell death is markedly decreased in response to avirulent bacterial strains. After induction by an avirulent pathogen recognition signal, OsNAC4 is translocated into the nucleus in a phosphorylation-dependent manner. A microarray analysis showed that the expression of 139 genes including OsHSP90 and IREN, encoding a Ca(2+)-dependent nuclease, were different between the OsNAC4 knock-down line and control line during HR cell death. During the induction of HR cell death, OsHSP90 is involved in the loss of plasma membrane integrity, whereas IREN causes nuclear DNA fragmentation. Overall, our results indicate that two important events occurring during HR cell death are regulated by independent pathways.
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