ArticleNature clinical practice. Endocrinology & metabolism2009
Does combined hormone replacement therapy improve the health-related quality of life of postmenopausal women?
Article in Nature clinical practice. Endocrinology & metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders.Science translational medicine · 2015Article
Corrections and comments
- Comment on
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This Practice Point commentary discusses the findings and limitations of a study by Welton et al. that assessed the effect of combined hormone replacement therapy (HRT) on health-related quality of life (QOL) in postmenopausal women. Evidence of the effect of HRT on health-related QOL in this group of patients in prior literature has been lacking, in part because of the varied, nonvalidated instruments used for evaluation. Welton et al. overcame that issue by the use of multiple questionnaires, and included specific questions on sexual functioning. However, all studies on health-related QOL are limited by the subjective selection of the parameters included in the instruments. Within this limitation, these authors concluded that HRT (estrogen alone in women without a uterus, and estrogen plus progestin for women with a uterus) offers more benefit than risk for postmenopausal, symptomatic women.
Identifiers
19229231What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.