ArticleNature clinical practice. Endocrinology & metabolism2009
Do short courses of oral corticosteroids and use of inhaled corticosteroids affect bone health in children?
Article in Nature clinical practice. Endocrinology & metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
This Practice Point commentary discusses the findings of a prospective study by Kelly et al. that evaluated the effect of multiple short courses of oral corticosteroids and use of inhaled corticosteroids on bone accrual in children with asthma. The researchers determined the cumulative number of short courses of oral corticosteroids and the cumulative dose of inhaled corticosteroids over a 7-year study period. Multiple short courses of oral corticosteroids in boys, but not girls, were a dose-dependent risk factor for decreased bone-mineral accrual and osteopenia. Inhaled corticosteroid use in boys, but not girls, was also associated with decreased bone accrual, but the association was not dose-dependent. However, no effect of corticosteroids on fracture risk was found. Here, I discuss the relevance of these findings in relation to attainment of peak bone mass and outline how the findings could be complicated by disease-related effects of asthma on bone health.
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