ReviewRNA biology
Regulation of imprinted expression by macro non-coding RNAs.
Review in RNA biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Transcription regulation by long non-coding RNAs: mechanisms and disease relevance.Nature reviews. Molecular cell biology · 2024Review
- Imprinted Long Non-Coding RNAs in Mammalian Development and Disease.International journal of molecular sciences · 2023Review
- The tumor therapeutic potential of long non-coding RNA delivery and targeting.Acta pharmaceutica Sinica. B · 2023Review
- The Role of Long Non-coding RNAs in Human Imprinting Disorders: Prospective Therapeutic Targets.Frontiers in cell and developmental biology · 2021Review
- Long noncoding RNA functionality in imprinted domain regulation.PLoS genetics · 2020Review
- Transcriptional gene silencing in humans.Nucleic acids research · 2016Article
- Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions.Nature communications · 2016Article
- A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus.Nature communications · 2015Article
- A pathophysiological view of the long non-coding RNA world.Oncotarget · 2014Review
- De novo transcriptome hybrid assembly and validation in the European earwig (Dermaptera, Forficula auricularia).PloS one · 2014Article
- Maintenance of epigenetic information: a noncoding RNA perspective.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- LINE-1 activation and epigenetic silencing of suppressor genes in cancer: Causally related events?Mobile genetic elements · 2013Article
- VlincRNAs controlled by retroviral elements are a hallmark of pluripotency and cancer.Genome biology · 2013Article
- Long non-coding RNA targeting and transcriptional de-repression.Nucleic acid therapeutics · 2013Review
- Neurodegeneration as an RNA disorder.Progress in neurobiology · 2012Review
- The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart.PLoS genetics · 2012Article
- Ube3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3a.Human molecular genetics · 2012Article
- Genomic imprinting and epigenetic control of development.Cold Spring Harbor perspectives in biology · 2012Article
- H19 antisense RNA can up-regulate Igf2 transcription by activation of a novel promoter in mouse myoblasts.PloS one · 2012Article
- Non-coding RNA and antisense RNA. Nature's trash or treasure?Biochimie · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
In mammals, imprinted genes are clustered and at least one gene in each imprinted cluster is a long i.e., macro non-coding (nc) RNA. Most genes in a cluster show concordant parental-specific expression but the ncRNA is the odd one out, and is expressed from the opposite parental chromosome. While reciprocal expression between imprinted macro non-coding RNAs and flanking mRNA genes is indicative of a functional role, only two of three tested macro ncRNAs have been shown to induce imprinted gene expression. The two known functional imprinted macro non-coding RNAs are both RNAPII transcripts with unusual transcriptional properties that may be functionally relevant and their analysis may shed light on the function of non-coding RNAs that have been shown to comprise the majority of the mammalian transcriptome.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.