ArticleCirculation research2009
Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach.
Article in Circulation research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- Effects of dietary nitrate supplementation on microvascular physiology at 4559 m altitude - A randomised controlled trial (Xtreme Alps).Nitric oxide : biology and chemistry · 2020Trial
- Short-term intravenous sodium nitrite infusion improves cardiac and pulmonary hemodynamics in heart failure patients.Circulation. Heart failure · 2015Trial
- Dysregulation of cardiac mitochondrial aldehyde dehydrogenase 2: Studies in dogs with chronic heart failure.Journal of molecular and cellular cardiology plus · 2024Article
- Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling.Cardiovascular research · 2020Article
- Molecular Bases of Brain Preconditioning.Frontiers in neuroscience · 2017Article
- Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans.British journal of pharmacology · 2015Article
- Short-term hypoxic vasodilation in vivo is mediated by bioactive nitric oxide metabolites, rather than free nitric oxide derived from haemoglobin-mediated nitrite reduction.The Journal of physiology · 2014Article
- Inorganic nitrite supplementation for healthy arterial aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Review
- Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion.Cardiovascular research · 2014Article
- Mitochondrial uncoupler carbonyl cyanide M-chlorophenylhydrazone induces the multimer assembly and activity of repair enzyme protein L-isoaspartyl methyltransferase.Journal of molecular neuroscience : MN · 2013Article
- Impact of mitochondria on nitrite metabolism in HL-1 cardiomyocytes.Frontiers in physiology · 2013Article
- Dietary inorganic nitrate alleviates doxorubicin cardiotoxicity: mechanisms and implications.Nitric oxide : biology and chemistry · 2012Review
- Mutagenesis of surfactant protein D informed by evolution and x-ray crystallography enhances defenses against influenza A virus in vivo.The Journal of biological chemistry · 2011Article
- What can we learn about cardioprotection from the cardiac mitochondrial proteome?Cardiovascular research · 2010Review
- Mitochondrial aldehyde dehydrogenase and cardiac diseases.Cardiovascular research · 2010Review
- Potentially fatal new trend in performance enhancement: a cautionary note on nitrite.Journal of the International Society of Sports Nutrition · 2010Article
- Proteomics and mass spectrometry: what have we learned about the heart?Current cardiology reviews · 2010Article
- Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice.Journal of molecular and cellular cardiology · 2010Article
- Mitochondria as metabolizers and targets of nitrite.Nitric oxide : biology and chemistry · 2010Review
- Protein S-nitrosylation and cardioprotection.Circulation research · 2010Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Nitrite has recently emerged as an important bioactive molecule, capable of conferring cardioprotection and a variety of other benefits in the cardiovascular system and elsewhere. The mechanisms by which it accomplishes these functions remain largely unclear. To characterize the dose response and corresponding cardiac sequelae of transient systemic elevations of nitrite, we assessed the time course of oxidation/nitros(yl)ation, as well as the metabolomic, proteomic, and associated functional changes in rat hearts following acute exposure to nitrite in vivo. Transient systemic nitrite elevations resulted in: (1) rapid formation of nitroso and nitrosyl species; (2) moderate short-term changes in cardiac redox status; (3) a pronounced increase in selective manifestations of long-term oxidative stress as evidenced by cardiac ascorbate oxidation, persisting long after changes in nitrite-related metabolites had normalized; (4) lasting reductions in glutathione oxidation (GSSG/GSH) and remarkably concordant nitrite-induced cardioprotection, which both followed a complex dose-response profile; and (5) significant nitrite-induced protein modifications (including phosphorylation) revealed by mass spectrometry-based proteomic studies. Altered proteins included those involved in metabolism (eg, aldehyde dehydrogenase 2, ubiquinone biosynthesis protein CoQ9, lactate dehydrogenase B), redox regulation (eg, protein disulfide isomerase A3), contractile function (eg, filamin-C), and serine/threonine kinase signaling (eg, protein kinase A R1alpha, protein phosphatase 2A A R1-alpha). Thus, brief elevations in plasma nitrite trigger a concerted cardioprotective response characterized by persistent changes in cardiac metabolism, redox stress, and alterations in myocardial signaling. These findings help elucidate possible mechanisms of nitrite-induced cardioprotection and have implications for nitrite dosing in therapeutic regimens.
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Registered trials
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