ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Ca2+ -calmodulin feedback mediates sensory adaptation and inhibits pheromone-sensitive ion channels in the vomeronasal organ.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- Chemosensory Receptors in Vertebrates: Structure and Computational Modeling Insights.International journal of molecular sciences · 2025Review
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Contribution of membrane-associated oscillators to biological timing at different timescales.Frontiers in physiology · 2023Article
- Optical Activation of Photoswitchable TRPC Ligands in the Mammalian Olfactory System Using Laser Scanning Confocal Microscopy.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The Bruce effect: Representational stability and memory formation in the accessory olfactory bulb of the female mouse.Cell reports · 2022Article
- The De-Scent of Sexuality: Did Loss of a Pheromone Signaling Protein Permit the Evolution of Same-Sex Sexual Behavior in Primates?Archives of sexual behavior · 2021Article
- A diacylglycerol photoswitching protocol for studying TRPC channel functions in mammalian cells and tissue slices.STAR protocols · 2021Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- In-vivo activation of vomeronasal neurons shows adaptive responses to pheromonal stimuli.Scientific reports · 2018Article
- Type 3 inositol 1,4,5-trisphosphate receptor is dispensable for sensory activation of the mammalian vomeronasal organ.Scientific reports · 2017Article
- Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.Chemical senses · 2016Article
- Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons.The Journal of general physiology · 2015Article
- Extracellular pH regulates excitability of vomeronasal sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- TRICK or TRP? What Trpc2(-/-) mice tell us about vomeronasal organ mediated innate behaviors.Frontiers in neuroscience · 2015Article
- Article
- Understanding system dynamics of an adaptive enzyme network from globally profiled kinetic parameters.BMC systems biology · 2014Article
- Physiological characterization of formyl peptide receptor expressing cells in the mouse vomeronasal organ.Frontiers in neuroanatomy · 2014Article
- Article
- Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons.Nature communications · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian vomeronasal organ (VNO) mediates the regulation of social behaviors by complex chemical signals. These cues trigger transient elevations of intracellular Ca(2+) in vomeronasal sensory neurons (VSNs), but the functional role of such Ca(2+) elevations is unknown. We show that stimulus-induced Ca(2+) entry plays an essential role as a negative feedback regulator of VSN sensitivity. Electrophysiological VSN responses undergo effective sensory adaptation that requires the influx of Ca(2+) and is mediated by calmodulin (CaM). Removal of the Ca(2+)-CaM feedback eliminates this form of adaptation. A key target of this feedback module is the pheromone-sensitive TRPC2-dependent cation channel of VSNs, as its activation is strongly inhibited by Ca(2+)-CaM. Our results reveal a previously unrecognized CaM-signaling pathway that endows the VSNs with a mechanism for adjusting gain and sensitivity of chemosensory signaling in the VNO.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.