ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
External tufted cells drive the output of olfactory bulb glomeruli.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
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107 citing papers in PubMed.
- The HCN4 channel modulates external tufted cell burst firing.Journal of neurophysiology · 2026Article
- Rapid temporal processing in the olfactory bulb underlies concentration-invariant odor identification and signal decorrelation.Nature neuroscience · 2026Article
- Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR-Dependent Translational Control of Synaptic Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Connexin 36-mediated gap junctions contribute to fine odour discrimination and late-phase excitation of mitral cells in the mouse olfactory bulb.The Journal of physiology · 2026Article
- Physiopathology of nasal and ecnomotopic olfactory receptors: focus on molecular pathways and potential pharmacological modulation.Frontiers in pharmacology · 2026Review
- The superficial tufted and mitral cell output neurons of the mouse olfactory bulb have dual roles in insulin sensing.Journal of cell science · 2025Article
- Sister external tufted cells form dynamic intraglomerular ensembles representing odor identity and concentration.iScience · 2025Article
- Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model.Journal of neuroinflammation · 2025Article
- Ultrastructural Contributions to Extrasynaptic Glutamatergic Signaling in Olfactory Bulb Glomeruli.The Journal of comparative neurology · 2025Article
- Article
- Elevated reactive aggression in forebrain-specificJournal of cell communication and signaling · 2024Article
- Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb.PLoS biology · 2024Article
- Firing Patterns of Mitral Cells and Their Transformation in the Main Olfactory Bulb.Brain sciences · 2024Article
- Imaging different cell populations in the mouse olfactory bulb using the genetically encoded voltage indicator ArcLight.Neurophotonics · 2024Review
- Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb.bioRxiv : the preprint server for biology · 2024Article
- Vasopressin differentially modulates the excitability of rat olfactory bulb neuron subtypes.Frontiers in neural circuits · 2024Article
- Circuit formation and sensory perception in the mouse olfactory system.Frontiers in neural circuits · 2024Review
- Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination.Cell reports · 2023Article
- Hyperexcitability in the Olfactory Bulb and Impaired Fine Odor Discrimination in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neuropsychiatric consequences of COVID-19 related olfactory dysfunction: could non-olfactory cortical-bound inputs from damaged olfactory bulb also contribute to cognitive impairment?Frontiers in neuroscience · 2023Article
47 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Odors synchronize the activity of olfactory bulb mitral cells that project to the same glomerulus. In vitro, a slow rhythmic excitation intrinsic to the glomerular network persists, even in the absence of afferent input. We show here that a subpopulation of juxtaglomerular cells, external tufted (ET) cells, may trigger this rhythmic activity. We used paired whole-cell recording and Ca(2+) imaging in bulb slices from wild-type and transgenic mice expressing the fluorescent Ca(2+) indicator protein GCaMP-2. Slow, periodic population bursts in mitral cells were synchronized with spontaneous discharges in ET cells. Moreover, activation of a single ET cell was sufficient to evoke population bursts in mitral cells within the same glomerulus. Stimulation of the olfactory nerve induced similar population bursts and activated ET cells at a lower threshold than mitral cells, suggesting that ET cells mediate feedforward excitation of mitral cells. We propose that ET cells act as essential drivers of glomerular output to the olfactory cortex.
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