ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Effects of gender on gene expression in the blood of ischemic stroke patients.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Trial
- Hormonal regulatory networks in spinal cord injury: mechanistic insights, crosstalk, and therapeutic innovations.Frontiers in endocrinology · 2025Review
- Targeting Remyelination in Spinal Cord Injury: Insights and Emerging Therapeutic Strategies.CNS neuroscience & therapeutics · 2024Review
- Effects of grape seed proanthocyanidin extract on side effects of high-dose methylprednisolone administration in male rats.Toxicological research · 2023Article
- Functional State of the Motor Centers of the Lumbar Spine after Contusion (Th8-Th9) with Application of Methylprednisolone-Copolymer at the Site of Injury.Biomedicines · 2023Article
- Role of stress-related glucocorticoid changes in astrocyte-oligodendrocyte interactions that regulate myelin production and maintenance.Histology and histopathology · 2023Review
- Effects of Long-Term Endogenous Corticosteroid Exposure on Brain Volume and Glial Cells in the AdKO Mouse.Frontiers in neuroscience · 2021Article
- Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets.Croatian medical journal · 2019Review
- Mechanism of Neuroprotection Against Experimental Spinal Cord Injury by Riluzole or Methylprednisolone.Neurochemical research · 2019Review
- Methylprednisolone treatment enhances early recovery following surgical decompression for degenerative cervical myelopathy without compromise to the systemic immune system.Journal of neuroinflammation · 2018Article
- Prophylactic and therapeutic functions of drug combinations against noise-induced hearing loss.Hearing research · 2013Article
- Protective effect of ginkgolide B against acute spinal cord injury in rats and its correlation with the Jak/STAT signaling pathway.Neurochemical research · 2013Article
- The role of JAK-STAT signaling within the CNS.JAK-STAT · 2013Review
- Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity.The Journal of biological chemistry · 2012Article
- Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis.PloS one · 2012Article
- Activation of STAT1 in neurons following spinal cord injury in mice.Neurochemical research · 2011Article
- A novel microRNA mmu-miR-466h affects apoptosis regulation in mammalian cells.Biotechnology and bioengineering · 2011Article
- Clinical and experimental advances in regeneration of spinal cord injury.Journal of tissue engineering · 2010Article
- Glucocorticoid protection of oligodendrocytes against excitotoxin involving hypoxia-inducible factor-1alpha in a cell-type-specific manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The role of glucocorticoids for spiral ganglion neuron survival.Brain research · 2009Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Methylprednisolone (MP), a synthetic glucocorticoid agonist, is widely used for the clinical therapy of white matter diseases in the nervous system, such as spinal cord injury and multiple sclerosis. In addition to its potent anti-inflammatory and antioxidant properties, we recently discovered a selective antiapoptotic effect of MP on oligodendrocytes via the activation of the glucocorticoid receptor (GR) and the upregulation of bcl-X(L), a splicing isoform of the bcl-x gene. Based on published findings of the functional interactions between GR and STAT5, a transcription factor from the family of signal transducers and activators of transcription (STAT), we examined whether the glucocorticoid signaling pathway interacts with STAT5 to upregulate bcl-X(L) and protect oligodendrocytes. We show herein that (1) the GR and STAT5 complex is present on the STAT5-binding site of the bcl-x promoter region in oligodendrocytes; (2) the overexpression of an activated form of STAT5 prevents alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced oligodendrocyte cell death; and (3) this prevention is lost when the STAT5 gene is knocked down. Thus, our results provide one molecular mechanism underlying the postinjury protective effects of oligodendrocytes by stress hormones.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.