ArticleEndocrinology2009
The xenoestrogen bisphenol A inhibits postembryonic vertebrate development by antagonizing gene regulation by thyroid hormone.
Article in Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- The Impact of Bisphenol A on Thyroid Function in Neonates and Children: A Systematic Review of the Literature.Nutrients · 2021Pooled it
- Investigating Sexual Characteristics in Two Frog Species Under Exposure to River Water Polluted with Endocrine Disruptors.Animals : an open access journal from MDPI · 2025Article
- Review
- Environmental Exposure to Bisphenol A Enhances Invasiveness in Papillary Thyroid Cancer.International journal of molecular sciences · 2025Article
- Relationship between bisphenol A and autoimmune thyroid disease in women of childbearing age.Frontiers in endocrinology · 2024Article
- Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions.Pharmaceutics · 2023Review
- Article
- The Role of Estrogen and Thyroid Hormones in Zebrafish Visual System Function.Frontiers in pharmacology · 2022Review
- Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Article
- Maternal urinary bisphenol A concentration and thyroid hormone levels of Chinese mothers and newborns by maternal body mass index.Environmental science and pollution research international · 2020Article
- Bisphenols and Thyroid Hormone.Endocrinology and metabolism (Seoul, Korea) · 2019Review
- Toxicity and multigenerational effects of bisphenol S exposure toToxicology research · 2019Article
- CLARITY-BPA: Bisphenol A or Propylthiouracil on Thyroid Function and Effects in the Developing Male and Female Rat Brain.Endocrinology · 2019Article
- Contaminant and Environmental Influences on Thyroid Hormone Action in Amphibian Metamorphosis.Frontiers in endocrinology · 2019Review
- Testing baby bottles for the presence of residual and migrated bisphenol A.Environmental monitoring and assessment · 2018Article
- An AOP-based alternative testing strategy to predict the impact of thyroid hormone disruption on swim bladder inflation in zebrafish.Aquatic toxicology (Amsterdam, Netherlands) · 2018Article
- Direct Regulation of Histidine Ammonia-Lyase 2 Gene by Thyroid Hormone in the Developing Adult Intestinal Stem Cells.Endocrinology · 2017Article
- The Sox transcriptional factors: Functions during intestinal development in vertebrates.Seminars in cell & developmental biology · 2017Review
- Metabolic and endocrine effects of bisphenol A exposure in market seller women with polycystic ovary syndrome.Environmental science and pollution research international · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Bisphenol A (BPA), a chemical widely used to manufacture plastics, is estrogenic and capable of disrupting sex differentiation. However, recent in vitro studies have shown that BPA can also antagonize T(3) activation of the T(3) receptor. The difficulty in studying uterus-enclosed mammalian embryos has hampered the analysis on the direct effects of BPA during vertebrate development. This study proposed to identify critical T(3) pathways that may be disrupted by BPA based on molecular analysis in vivo. Because amphibian metamorphosis requires T(3) and encompasses the postembryonic period in mammals when T(3) action is most critical, we used this unique model for studying the effect of BPA on T(3)-dependent vertebrate development at both the morphological and molecular levels. After 4 d of exposure, BPA inhibited T(3)-induced intestinal remodeling in premetamorphic Xenopus laevis tadpoles. Importantly, microarray analysis revealed that BPA antagonized the regulation of most T(3)-response genes, thereby explaining the inhibitory effect of BPA on metamorphosis. Surprisingly, most of the genes affected by BPA in the presence of T(3) were T(3)-response genes, suggesting that BPA predominantly affected T(3)-signaling pathways during metamorphosis. Our finding that this endocrine disruptor, well known for its estrogenic activity in vitro, functions to inhibit T(3) pathways to affect vertebrate development in vivo and thus not only provides a mechanism for the likely deleterious effects of BPA on human development but also demonstrates the importance of studying endocrine disruption in a developmental context in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.