ArticleStroke2009
Greater rupture risk for familial as compared to sporadic unruptured intracranial aneurysms.
Article in Stroke, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 4 syntheses or guidelines pooled it, 218 citations in OpenAlex.
- Radiological surveillance of small unruptured intracranial aneurysms: a systematic review, meta-analysis, and meta-regression of 8428 aneurysms.Neurosurgical review · 2021Pooled it
- A Meta-Analysis of Rupture Risk for Intracranial Aneurysms 10 mm or Less in Size Selected for Conservative Management Without Repair.Frontiers in neurology · 2021Pooled it
- Patient and aneurysm characteristics in familial intracranial aneurysms. A systematic review and meta-analysis.PloS one · 2019Pooled it
- Pooled it
- Mortality and causes of death in the Familial Intracranial Aneurysm study.International journal of stroke : official journal of the International Stroke Society · 2013Trial
- A single-cell atlas of intracranial aneurysm progression identifies a dysfunctional VSMC subpopulation associated with rupture risk.BMC neuroscience · 2026Article
- Endovascular electrocoagulation for treating a blister-like microaneurysm with an extremely narrow neck: A case report.World journal of clinical cases · 2025Article
- Evidence-based fitness-to-fly assessment for military aviators with untreated unruptured intracranial aneurysms: A 5-year retrospective at a single center.Neurosurgical review · 2025Article
- Cost-effectiveness of population-wide screening for intracranial aneurysms revisited in light of potential diagnostic developments.International journal of stroke : official journal of the International Stroke Society · 2025Article
- Treatment of small intracranial aneurysms using the SMALLSS scoring system: a novel system for decision making.Acta neurochirurgica · 2025Article
- Effect of Collagen Fiber Tortuosity Distribution on the Mechanical Response of Arterial Tissues.Journal of biomechanical engineering · 2025Article
- Intermediate catheter use is associated with complete occlusion and dense packing in coil embolization of unruptured cerebral aneurysms: a propensity score matched study.Journal of neurointerventional surgery · 2025Article
- Predicting early functional outcomes in aneurysmal subarachnoid hemorrhage in endovascular coiling and surgical clipping.Frontiers in neurology · 2025Article
- Article
- Complex networks approach to study comorbidities in patients with unruptured intracranial aneurysms.Scientific reports · 2024Article
- Article
- Article
- Diagnosis and management of subarachnoid haemorrhage.Nature communications · 2024Review
- Small molecule inhibitors target multiple neuropathological signaling to exert novel neuroprotection in intracranial aneurysms.Frontiers in pharmacology · 2024Review
- Nomograms for assessing the rupture risk of anterior choroid artery aneurysms based on clinical, morphological, and hemodynamic features.Frontiers in neurology · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 7 institutions in 3 countries.
Funding
Abstract
background and purposeThe risk of intracranial aneurysm (IA) rupture in asymptomatic members of families who have multiple affected individuals is not known.
methodsFirst-degree unaffected relatives of those with a familial history of IA who had a history of smoking or hypertension but no known IA were offered cerebral MR angiography (MRA) and followed yearly as part of a National Institute of Neurological Diseases and Stroke-funded study of familial IA (Familial Intracranial Aneurysm [FIA] Study).
resultsA total of 2874 subjects from 542 FIA Study families were enrolled. After study enrollment, MRAs were performed in 548 FIA Study family members with no known history of IA. Of these 548 subjects, 113 subjects (20.6%) had 148 IAs by MRA of whom 5 subjects had IA >or=7 mm. Two subjects with an unruptured IA by MRA/CT angiography (3-mm and 4-mm anterior communicating artery) subsequently had rupture of their IA. This represents an annual rate of 1.2 ruptures per 100 subjects (1.2% per year; 95% CI, 0.14% to 4.3% per year). None of the 435 subjects with a negative MRA have had a ruptured IA. Survival curves between the MRA-positive and -negative cohorts were significantly different (P=0.004). This rupture rate of unruptured IA in the FIA Study cohort of 1.2% per year is approximately 17 times higher than the rupture rate for subjects with an unruptured IA in the International Study of Unruptured Aneurysm Study with a matched distribution of IA size and location 0.069% per year.
conclusionsSmall unruptured IAs in patients from FIA Study families may have a higher risk of rupture than sporadic unruptured IAs of similar size, which should be considered in the management of these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.