ReviewThe journals of gerontology. Series A, Biological sciences and medical sciences2009
Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones.
Review in The journals of gerontology. Series A, Biological sciences and medical sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Six-month Calorie Restriction in Overweight Individuals Elicits Transcriptomic Response in Subcutaneous Adipose Tissue That is Distinct From Effects of Energy Deficit.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Trial
- Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Trial
- 'Adipaging': ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue.The Journal of physiology · 2016Review
- The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice.Experimental gerontology · 2015Article
- Mechanisms underlying the neuroprotective effect of brain reserve against late life depression.Journal of neural transmission (Vienna, Austria : 1996) · 2015Review
- Article
- The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse.Oncotarget · 2015Article
- CCAAT-enhancer binding protein (C/EBP) β regulates insulin-like growth factor (IGF) 1 expression in porcine liver during prenatal and postnatal development.Molecular and cellular biochemistry · 2015Article
- Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging.Aging cell · 2014Article
- Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system.Pharmacological reviews · 2014Review
- Dexmedetomidine preconditioning ameliorates kidney ischemia-reperfusion injury.Pharmacology research & perspectives · 2014Article
- Aging and energetics' 'Top 40' future research opportunities 2010-2013.F1000Research · 2014Review
- Article
- The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer.Critical reviews in oncology/hematology · 2013Review
- Age-dependent alteration in muscle regeneration: the critical role of tissue niche.Biogerontology · 2013Article
- Role of the hypothalamus in mediating protective effects of dietary restriction during aging.Frontiers in neuroendocrinology · 2013Review
- The rationale for delaying aging and the prevention of age-related diseases.Rambam Maimonides medical journal · 2012Article
- The place of genetics in ageing research.Nature reviews. Genetics · 2012Review
- Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging.Experimental gerontology · 2012Article
- Nectarine promotes longevity in Drosophila melanogaster.Free radical biology & medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calorie restriction and reduced somatotropic (growth hormone and insulin-like growth factor-1) signaling have a widespread though not universal ability to extend life. These interventions are considered central tools to understanding the downstream events that lead to the increase in healthy life span. As these approaches have been validated, the animals phenotyped, and the mechanisms proposed, many challenges have emerged. In this article, we give several examples and propose several considerations, opportunities, and approaches that may identify major mechanisms through which these interventions exert their effects, and which may lead to drug therapy to increase "health span."
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.