Evidence map›Paper›PMID 19228604›Full record

ReviewArteriosclerosis, thrombosis, and vascular biology2009

New insights into cancer-associated thrombosis.

Tarek Sousou, Alok A Khorana

Open access · bronzeAbstract readReview
In one paragraph

Review in Arteriosclerosis, thrombosis, and vascular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 80 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Impact of Transfusion on Cancer Growth and Outcome.Cancer growth and metastasis · 2016
    Review
  15. Article
  16. Article
  17. Venous thromboembolism and lung cancer: a review.Multidisciplinary respiratory medicine · 2015
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Tarek SousouJames P. Wilmot Cancer Center and the Department of Medicine, University of Rochester, NY, USA.
Alok A Khorana
University of Rochester Medical Center · US

Funding

Venous Thrombosis in Cancer Outpatients: Prevention and Role of Tissue FactorR01HL095109 · NHLBI · UNIVERSITY OF ROCHESTER · PI FRANCIS, CHARLES W. · 2008 to 2012
$3.2M
Risk Factors for Venous Thromboembolism in Cancer Patients Receiving ChemotherapyK23CA120587 · NCI · UNIVERSITY OF ROCHESTER · PI KHORANA, ALOK A · 2006 to 2010
$649k
NCI NIH HHS K23 CA120587NHLBI NIH HHS 1R01HL095109-01NHLBI NIH HHS R01 HL095109
6 · The paper itself

Abstract

Venous thromboembolism (VTE) is an increasingly frequent complication of anticancer therapy. The underlying mechanisms are not completely understood, but are related in part to oncogene activation and tissue factor (TF) expression. Several risk factors have been identified including site and stage of cancer, patient comorbidities, and specific therapeutic agents. Candidate biomarkers such as blood counts, TF, and P-selectin have recently been identified. A risk model predictive of chemotherapy-associated VTE has been validated. Thromboprophylaxis with low molecular weight heparin (LMWH), unfractionated heparin (UFH), or fondaparinux is recommended for hospitalized medical and surgical cancer patients. Long-term anticoagulation with LMWH is safe and effective in reducing recurrent VTE in cancer. The role of thromboprophylaxis in ambulatory cancer patients receiving chemotherapy is an area of active investigation.

Indexed as

AnticoagulantsAntineoplastic AgentsBiomarkersBlood CoagulationHumansNeoplasmsPredictive Value of TestsRisk AssessmentRisk FactorsSecondary PreventionTreatment OutcomeVenous ThromboembolismAnticoagulantsAntineoplastic AgentsBiomarkers

Identifiers

PMID19228604
PMCPMC2727713
OpenAlexW2129676747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.