ArticleBMC developmental biology2009
Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology].
Article in BMC developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- SDS-22 stabilizes GSP-1/-2 PP1 subunits contributing to polarity establishment in C. elegans embryos.EMBO reports · 2025Article
- SDS22 coordinates the assembly of holoenzymes from nascent protein phosphatase-1.Nature communications · 2024Article
- Article
- Cell-type-specific mechanical response and myosin dynamics during retinal lens development inMolecular biology of the cell · 2020Article
- Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1.Structure (London, England : 1993) · 2019Article
- Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway.Neoplasia (New York, N.Y.) · 2019Article
- Spatio-temporally separated cortical flows and spindle geometry establish physical asymmetry in fly neural stem cells.Nature communications · 2017Article
- Sara phosphorylation state controls the dispatch of endosomes from the central spindle during asymmetric division.Nature communications · 2017Article
- Article
- Coupling changes in cell shape to chromosome segregation.Nature reviews. Molecular cell biology · 2016Review
- Review
- Characterization of Genomic Variants Associated with Scout and Recruit Behavioral Castes in Honey Bees Using Whole-Genome Sequencing.PloS one · 2016Article
- ERM proteins at a glance.Journal of cell science · 2014Article
- Suppressors of ipl1-2 in components of a Glc7 phosphatase complex, Cdc48 AAA ATPase, TORC1, and the kinetochore.G3 (Bethesda, Md.) · 2012Article
- Modeling tumor invasion and metastasis in Drosophila.Disease models & mechanisms · 2011Review
- Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling.Oncogene · 2011Article
- Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis.Molecular biology of the cell · 2010Article
- A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium.PloS one · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHow epithelial cells adopt their particular polarised forms is poorly understood. In a screen for genes regulating epithelial morphology in Drosophila, we identified sds22, a conserved gene previously characterised in yeast.
resultsIn the columnar epithelia of imaginal discs or follicle cells, mutation of sds22 causes contraction of cells along their apical-basal axis, resulting in a more cuboidal morphology. In addition, the mutant cells can also display altered cell polarity, forming multiple layers in follicle cells and leaving the epithelium in imaginal discs. In yeast, sds22 encodes a PP1 phosphatase regulatory subunit. Consistent with this, we show that Drosophila Sds22 binds to all four Drosophila PP1s and shares an overlapping phenotype with PP1beta9c. We also show that two previously postulated PP1 targets, Spaghetti Squash and Moesin are hyper-phosphorylated in sds22 mutants. This function is shared by the human homologue of Sds22, PPP1R7.
conclusionSds22 is a conserved PP1 phosphatase regulatory subunit that controls cell shape and polarity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.