ArticleJournal of translational medicine2009
Species distribution and antimicrobial susceptibility of gram-negative aerobic bacteria in hospitalized cancer patients.
Article in Journal of translational medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 87 citations in OpenAlex.
- Molecular typing and virulence analysis of multidrug resistant Klebsiella pneumoniae clinical isolates recovered from Egyptian hospitals.Scientific reports · 2016Trial
- Bacterial profile, antimicrobial resistance patterns and associated factors among cancer patients at Hawassa University Comprehensive Specialized Hospital, Sidama region, Southern Ethiopia.BMC infectious diseases · 2026Article
- Phenotypic and genotypic characterization of carbapenem resistant Klebsiella pneumoniae clinical isolates from Damietta, Egypt.BMC microbiology · 2026Article
- Prevalence, microbiology, and antimicrobial susceptibility profile of bacterial skin and soft tissue infections in pediatric patients with malignancies at a referral teaching hospital in Shiraz, Iran.BMC infectious diseases · 2025Article
- Synergistic combination of ceftazidime and avibactam with Aztreonam against MDR Klebsiella pneumoniae in ICU patients.Scientific reports · 2025Article
- Unveiling the potential of spirulina algal extract as promising antibacterial and antibiofilm agent against carbapenem-resistant Klebsiella pneumoniae: in vitro and in vivo study.Microbial cell factories · 2025Article
- Navigating an evolving microbial landscape: emerging antimicrobial resistance trends and precision stewardship in Tianjin tertiary hospitals (2021-2023).Frontiers in cellular and infection microbiology · 2025Article
- Clinical Characteristics of Uncomplicated Acute Pyelonephritis Caused by Escherichia coli and Klebsiella pneumoniae.Infectious diseases and therapy · 2024Article
- Antibiotic susceptibility and virulence factors of bacterial species among cancer patients.Biotechnology notes (Amsterdam, Netherlands) · 2024Article
- Multidrug Resistant Enteric Bacteria from Cancer Patients Admitted in Douala Laquintinie Hospital, Littoral Region of Cameroon.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2024Article
- Infections in Children with Cancer Admitted in an Oncology Reference Hospital: A Cross-sectional Study.Current microbiology · 2023Article
- Adaptation of Bacteria to Antineoplastic Agents Involves Persister Cells and Increases Resistance to Antibiotics.Bioengineering (Basel, Switzerland) · 2022Article
- Microbial spectrum and drug resistance profile in solid malignancies in a large tertiary hospital from Palestine.BMC infectious diseases · 2022Article
- Frequency of microbial isolates and pattern of antimicrobial resistance in patients with hematological malignancies: a cross-sectional study from Palestine.BMC infectious diseases · 2022Article
- Establishment and validation of a nomogram to predict the in-hospital death risk of nosocomial infections in cancer patients.Antimicrobial resistance and infection control · 2022Article
- Carbapenem-ResistantInfection and drug resistance · 2022Article
- An overview of healthcare-associated infections in a tertiary care hospital in Egypt.Infection prevention in practice · 2020Article
- Nosocomial infections due to multidrug-resistant bacteria in cancer patients: a six-year retrospective study of an oncology Center in Western China.BMC infectious diseases · 2020Observational
- Evaluation of Antibiotic Resistance and Virulence Genes among Clinical Isolates of Pseudomonas aeruginosa from Cancer Patients.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Multiple Drug Resistance Patterns in Various Phylogenetic Groups of Hospital-Acquired UropathogenicAntibiotics (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNosocomial infections pose significant threats to hospitalized patients, especially the immunocompromised ones, such as cancer patients.
methodsThis study examined the microbial spectrum of gram-negative bacteria in various infection sites in patients with leukemia and solid tumors. The antimicrobial resistance patterns of the isolated bacteria were studied.
resultsThe most frequently isolated gram-negative bacteria were Klebsiella pneumonia (31.2%) followed by Escherichia coli (22.2%). We report the isolation and identification of a number of less-frequent gram negative bacteria (Chromobacterium violacum, Burkholderia cepacia, Kluyvera ascorbata, Stenotrophomonas maltophilia, Yersinia pseudotuberculosis, and Salmonella arizona). Most of the gram-negative isolates from Respiratory Tract Infections (RTI), Gastro-intestinal Tract Infections (GITI), Urinary Tract Infections (UTI), and Bloodstream Infections (BSI) were obtained from leukemic patients. All gram-negative isolates from Skin Infections (SI) were obtained from solid-tumor patients. In both leukemic and solid-tumor patients, gram-negative bacteria causing UTI were mainly Escherichia coli and Klebsiella pneumoniae, while gram-negative bacteria causing RTI were mainly Klebsiella pneumoniae. Escherichia coli was the main gram-negative pathogen causing BSI in solid-tumor patients and GITI in leukemic patients. Isolates of Escherichia coli, Klebsiella, Enterobacter, Pseudomonas, and Acinetobacter species were resistant to most antibiotics tested. There was significant imipenem -resistance in Acinetobacter (40.9%), Pseudomonas (40%), and Enterobacter (22.2%) species, and noticeable imipinem-resistance in Klebsiella (13.9%) and Escherichia coli (8%).
conclusionThis is the first study to report the evolution of imipenem-resistant gram-negative strains in Egypt. Mortality rates were higher in cancer patients with nosocomial Pseudomonas infections than any other bacterial infections. Policies restricting antibiotic consumption should be implemented to avoid the evolution of newer generations of antibiotic resistant-pathogens.
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