ArticleBMC neuroscience2009
Abnormal resting-state cortical coupling in chronic tinnitus.
Article in BMC neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
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Who cites it
111 citing papers in PubMed.
- Modulated Alpha Power as a Predictor of Tinnitus Alleviation.The journal of international advanced otology · 2024Trial
- A proof-of-concept study on the combination of repetitive transcranial magnetic stimulation and relaxation techniques in chronic tinnitus.Journal of neural transmission (Vienna, Austria : 1996) · 2016Trial
- The effectiveness of acupuncture as a treatment for tinnitus: a randomized controlled trial using (99m)Tc-ECD SPECT.European radiology · 2016Trial
- Triple-site rTMS for the treatment of chronic tinnitus: a randomized controlled trial.Scientific reports · 2016Trial
- Combined rTMS treatment targeting the Anterior Cingulate and the Temporal Cortex for the Treatment of Chronic Tinnitus.Scientific reports · 2015Trial
- Acoustic Coordinated Reset Neuromodulation in a Real Life Patient Population with Chronic Tonal Tinnitus.BioMed research international · 2015Trial
- Changes in motor cortex excitability associated with temporal repetitive transcranial magnetic stimulation in tinnitus: hints for cross-modal plasticity?BMC neuroscience · 2014Trial
- Reversing pathologically increased EEG power by acoustic coordinated reset neuromodulation.Human brain mapping · 2014Trial
- Functional near-infrared spectroscopy to probe state- and trait-like conditions in chronic tinnitus: a proof-of-principle study.Neural plasticity · 2014Trial
- Trial
- Parietal double-cone coil stimulation in tinnitus.Experimental brain research · 2012Trial
- Treatment of chronic tinnitus with repeated sessions of prefrontal transcranial direct current stimulation: outcomes from an open-label pilot study.Journal of neurology · 2012Trial
- Short- and long-lasting tinnitus relief induced by transcranial direct current stimulation.Journal of neurology · 2011Trial
- Bilateral dorsolateral prefrontal cortex modulation for tinnitus by transcranial direct current stimulation: a preliminary clinical study.Experimental brain research · 2010Trial
- Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity.Proceedings of the National Academy of Sciences of the United States of America · 2010Trial
- Tinnitus and tinnitus disorder: Genetic, neurobiological, and clinical differentiation.iScience · 2026Review
- Fronto-temporal Delta-gamma Imbalance as a Neural Correlate of Hyperacusis in Tinnitus: An Exploratory EEG Study.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026Article
- Tinnitus.Nature reviews. Disease primers · 2026Review
- Perceptual and neural biomarkers of distraction from an external sound source are not associated with tinnitus severity.bioRxiv : the preprint server for biology · 2026Article
- Shared and Individual Resting-State MEG Network Signatures of Tinnitus Revealed by Holistic Graph Learning.IEEE open journal of engineering in medicine and biology · 2026Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubjective tinnitus is characterized by an auditory phantom perception in the absence of any physical sound source. Consequently, in a quiet environment, tinnitus patients differ from control participants because they constantly perceive a sound whereas controls do not. We hypothesized that this difference is expressed by differential activation of distributed cortical networks.
resultsThe analysis was based on a sample of 41 participants: 21 patients with chronic tinnitus and 20 healthy control participants. To investigate the architecture of these networks, we used phase locking analysis in the 1-90 Hz frequency range of a minute of resting-state MEG recording. We found: 1) For tinnitus patients: A significant decrease of inter-areal coupling in the alpha (9-12 Hz) band and an increase of inter-areal coupling in the 48-54 Hz gamma frequency range relative to the control group. 2) For both groups: an inverse relationship (r = -.71) of the alpha and gamma network coupling. 3) A discrimination of 83% between the patient and the control group based on the alpha and gamma networks. 4) An effect of manifestation on the distribution of the gamma network: In patients with a tinnitus history of less than 4 years, the left temporal cortex was predominant in the gamma network whereas in patients with tinnitus duration of more than 4 years, the gamma network was more widely distributed including more frontal and parietal regions.
conclusionIn the here presented data set we found strong support for an alteration of long-range coupling in tinnitus. Long-range coupling in the alpha frequency band was decreased for tinnitus patients while long-range gamma coupling was increased. These changes discriminate well between tinnitus and control participants. We propose a tinnitus model that integrates this finding in the current knowledge about tinnitus. Furthermore we discuss the impact of this finding to tinnitus therapies using Transcranial Magnetic Stimulation (TMS).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.