ArticleBMC medical genetics2009
Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry.
Article in BMC medical genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Replication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries.PloS one · 2014Pooled it
- Omics Approaches in Adipose Tissue and Skeletal Muscle Addressing the Role of Extracellular Matrix in Obesity and Metabolic Dysfunction.International journal of molecular sciences · 2021Review
- Advances in Understanding TKS4 and TKS5: Molecular Scaffolds Regulating Cellular Processes from Podosome and Invadopodium Formation to Differentiation and Tissue Homeostasis.International journal of molecular sciences · 2020Review
- Association of obesity with proteasomal gene polymorphisms in children.Journal of obesity · 2013Article
- Network graph analysis of gene-gene interactions in genome-wide association study data.Genomics & informatics · 2012Article
- Beyond the fourth wave of genome-wide obesity association studies.Nutrition & diabetes · 2012Article
- Genome wide association study identifies KCNMA1 contributing to human obesity.BMC medical genomics · 2011Article
- Recent progress in the genetics of common obesity.British journal of clinical pharmacology · 2009Review
- The podosomal-adaptor protein SH3PXD2B is essential for normal postnatal development.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA recent genome-wide association (GWA) study of U.S. Caucasians suggested that eight single nucleotide polymorphisms (SNPs) in CTNNBL1 are associated with obesity and increased fat mass. We analysed the respective SNPs in data from our previously published GWA for early onset obesity (case-control design), in GWA data from a population-based cohort of adults, and in an independent family-based obesity study. We investigated whether variants in CTNNBL1 (including rs6013029) and in three other genes (SH3PXD2B, SLIT3 and FLJ42133,) were associated with obesity.
methodsThe GWA studies were carried out using Affymetrix(R) SNP Chips with approximately 500,000 markers each. In the families, SNP rs6013029 was genotyped using the TaqMan(R) allelic discrimination assay. The German case-control GWA included 487 extremely obese children and adolescents and 442 healthy lean individuals. The adult GWA included 1,644 individuals from a German population-based study (KORA). The 775 independent German families consisted of extremely obese children and adolescents and their parents.
resultsWe found no evidence for an association of the reported variants in CTNNBL1 with early onset obesity or increased BMI. Further, in our family-based study we found no evidence for over-transmission of the rs6013029 risk-allele T to obese children. Additionally, we found no evidence for an association of SH3PXD2B, SLIT3 and FLJ42133 variants in our two GWA samples.
conclusionWe detected no confirmation of the recent association of variants in CTNNBL1 with obesity in a population of Central European ancestry.
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