ArticleThe Plant journal : for cell and molecular biology2009
POT1-independent single-strand telomeric DNA binding activities in Brassicaceae.
Article in The Plant journal : for cell and molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- A Nested PCR Telomere Fusion Assay Highlights the Widespread End-Capping Protection of Arabidopsis CTC1.International journal of molecular sciences · 2024Article
- Back to the future: The intimate and evolving connection between telomere-related factors and genotoxic stress.The Journal of biological chemistry · 2019Review
- Evolution of Arabidopsis protection of telomeres 1 alters nucleic acid recognition and telomerase regulation.Nucleic acids research · 2016Article
- Telomere- and Telomerase-Associated Proteins and Their Functions in the Plant Cell.Frontiers in plant science · 2016Review
- Evolution of the Telomere-Associated Protein POT1a in Arabidopsis thaliana Is Characterized by Positive Selection to Reinforce Protein-Protein Interaction.Molecular biology and evolution · 2015Article
- Telomere stability and development of ctc1 mutants are rescued by inhibition of EJ recombination pathways in a telomerase-dependent manner.Nucleic acids research · 2014Article
- Telomerase-dependent 3' G-strand overhang maintenance facilitates GTBP1-mediated telomere protection from misplaced homologous recombination.The Plant cell · 2013Article
- An alternative telomerase RNA in Arabidopsis modulates enzyme activity in response to DNA damage.Genes & development · 2012Article
- Screening a cDNA library for protein-protein interactions directly in planta.The Plant cell · 2012Article
- Surprises from the chromosome front: lessons from Arabidopsis on telomeres and telomerase.Cold Spring Harbor symposia on quantitative biology · 2012Article
- Selaginella moellendorffii telomeres: conserved and unique features in an ancient land plant lineage.Frontiers in plant science · 2012Article
- Arabidopsis ATM and ATR kinases prevent propagation of genome damage caused by telomere dysfunction.The Plant cell · 2011Article
- Roles of NtGTBP1 in telomere stability.Plant signaling & behavior · 2011Article
- Two RNA subunits and POT1a are components of Arabidopsis telomerase.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Comparative biology of telomeres: where plants stand.FEBS letters · 2010Review
- Pot1 and telomere maintenance.FEBS letters · 2010Review
- Evolution of CST function in telomere maintenance.Cell cycle (Georgetown, Tex.) · 2010Review
- Tobacco GTBP1, a homolog of human heterogeneous nuclear ribonucleoprotein, protects telomeres from aberrant homologous recombination.The Plant cell · 2010Article
- Protection of Telomeres 1 is required for telomere integrity in the moss Physcomitrella patens.The Plant cell · 2010Article
- HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner.The EMBO journal · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Telomeres define the ends of linear eukaryotic chromosomes and are required for genome maintenance and continued cell proliferation. The extreme ends of telomeres terminate in a single-strand protrusion, termed the G-overhang, which, in vertebrates and fission yeast, is bound by evolutionarily conserved members of the POT1 (protection of telomeres) protein family. Unlike most other model organisms, the flowering plant Arabidopsis thaliana encodes two divergent POT1-like proteins. Here we show that the single-strand telomeric DNA binding activity present in A. thaliana nuclear extracts is not dependent on POT1a or POT1b proteins. Furthermore, in contrast to POT1 proteins from yeast and vertebrates, recombinant POT1a and POT1b proteins from A. thaliana, and from two additional Brassicaceae species, Arabidopsis lyrata and Brassica oleracea (cauliflower), fail to bind single-strand telomeric DNA in vitro under the conditions tested. Finally, although we detected four single-strand telomeric DNA binding activities in nuclear extracts from B. oleracea, partial purification and DNA cross-linking analysis of these complexes identified proteins that are smaller than the predicted sizes of BoPOT1a or BoPOT1b. Taken together, these data suggest that POT1 proteins are not the major single-strand telomeric DNA binding activities in A. thaliana and its close relatives, underscoring the remarkable functional divergence of POT1 proteins from plants and other eukaryotes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.