Evidence map›Paper›PMID 19228277›Full record

ReviewJournal of oral rehabilitation2009

Tissue engineering: state of the art in oral rehabilitation.

E L Scheller, P H Krebsbach, D H Kohn

Open access · greenAbstract readReview
In one paragraph

Review in Journal of oral rehabilitation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 171 citations in OpenAlex.

  1. Article
  2. Characterization of Polylactic Acid Membranes for Local Release of Tramadol.International journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Dental Pulp Stem Cells for Salivary Gland Regeneration-Where Are We Today?International journal of molecular sciences · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Effect of Magnesium on Dentinogenesis of Human Dental Pulp Cells.International journal of biomaterials · 2021
    Article
  18. Article
  19. Review
  20. Present and future of tissue engineering scaffolds for dentin-pulp complex regeneration.Journal of tissue engineering and regenerative medicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

E L SchellerDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078, USA.
P H Krebsbach
D H Kohn
University of Michigan–Ann Arbor · US

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
3-D BIOMIMETIC SCAFFOLDS FOR BONE TISSUE ENGINEERINGR01DE013380 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOHN, DAVID H. · 2001 to 2011
$2.2M
BONE MARROW STROMAL CELLS FOR SKELETAL REGENERATIONR01DE013835 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KREBSBACH, PAUL H · 2001 to 2005
$1.3M
Organic/Inorganic Hybrids to Guide Bone RegenerationR01DE015411 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOHN, DAVID H. · 2003 to 2006
$1.2M
3-D Biomimetic Scaffolds for Bone Tissue EngineeringR56DE013380 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOHN, DAVID H. · 2007 to 2007
$375k
A Role of Osteoimmunology in Leptin-Regulated Bone MetabolismF30DE019577 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHELLER, ERICA LYNN · 2008 to 2010
$121k
NIDCR NIH HHS F30 DE019577NIDCR NIH HHS R01 DE 013380NIDCR NIH HHS R01 DE013380NIDCR NIH HHS R01 DE013835NIDCR NIH HHS R01 DE015411NIDCR NIH HHS R01 DE 13835NIDCR NIH HHS R56 DE013380NIDCR NIH HHS T32 DE007057NIDCR NIH HHS T32 DE07057
6 · The paper itself

Abstract

More than 85% of the global population requires repair or replacement of a craniofacial structure. These defects range from simple tooth decay to radical oncologic craniofacial resection. Regeneration of oral and craniofacial tissues presents a formidable challenge that requires synthesis of basic science, clinical science and engineering technology. Identification of appropriate scaffolds, cell sources and spatial and temporal signals (the tissue engineering triad) is necessary to optimize development of a single tissue, hybrid organ or interface. Furthermore, combining the understanding of the interactions between molecules of the extracellular matrix and attached cells with an understanding of the gene expression needed to induce differentiation and tissue growth will provide the design basis for translating basic science into rationally developed components of this tissue engineering triad. Dental tissue engineers are interested in regeneration of teeth, oral mucosa, salivary glands, bone and periodontium. Many of these oral structures are hybrid tissues. For example, engineering the periodontium requires growth of alveolar bone, cementum and the periodontal ligament. Recapitulation of biological development of hybrid tissues and interfaces presents a challenge that exceeds that of engineering just a single tissue. Advances made in dental interface engineering will allow these tissues to serve as model systems for engineering other tissues or organs of the body. This review will begin by covering basic tissue engineering principles and strategic design of functional biomaterials. We will then explore the impact of biomaterials design on the status of craniofacial tissue engineering and current challenges and opportunities in dental tissue engineering.

Indexed as

AnimalsBiocompatible MaterialsBone RegenerationDermatologic Surgical ProceduresHumansMouthMouth MucosaTemporomandibular JointTissue EngineeringTissue ScaffoldsToothBiocompatible Materials

Identifiers

PMID19228277
PMCPMC2744808
OpenAlexW2132712656

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.