ArticleJournal of cellular and molecular medicine2009
Regeneration of bone and periodontal ligament induced by recombinant amelogenin after periodontitis.
Article in Journal of cellular and molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- A modified method for inducing periodontitis in dogs using a silk-wire twisted ligature.Journal of veterinary science · 2012Trial
- Hydrophilic-Stable Nucleoside-Based Hydrogen-Bonded Organic Frameworks (N-HOF) for Therapeutic Bacterial Hybrid Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- A Biomimetic Amelogenin-Fibronectin Fusion Protein with Dual Cell-Adhesive and Osteoinductive Functions for Alveolar Bone Defect Repair.Bioengineering (Basel, Switzerland) · 2026Article
- Recombinant Amelogenin as a Potential Alternative to Enamel Matrix Derivatives in Periodontal Regeneration: A Scoping Review of Its Biological Activity, Synthesis and Delivery Systems.Clinical and experimental dental research · 2026Article
- Amelogenin Null Mice Develop Osteoarthritis, While Its Application Mitigates Disease Phenotypes in a Rat Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Histological evaluation following treatment of recession-type defects with coronally advanced flap and a novel human recombinant amelogenin.Clinical oral investigations · 2023Article
- Review
- Mineralized nanofiber segments coupled with calcium-binding BMP-2 peptides for alveolar bone regeneration.Acta biomaterialia · 2019Article
- Recombinant amelogenin regulates the bioactivity of mouse cementoblasts in vitro.International journal of oral science · 2018Article
- Effect of EMD on the orthodontically induced root resorption repair process in rats.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2018Article
- Skeletal ligament healing using the recombinant human amelogenin protein.Journal of cellular and molecular medicine · 2016Article
- Expression of Recombinant Human Amelogenin in Iranian Lizard Leishmania and Its Biological Function Assay.Iranian journal of public health · 2015Article
- Animal models for periodontal regeneration and peri-implant responses.Periodontology 2000 · 2015Review
- Article
- Image-based, fiber guiding scaffolds: a platform for regenerating tissue interfaces.Tissue engineering. Part C, Methods · 2014Article
- Tracking endogenous amelogenin and ameloblastin in vivo.PloS one · 2014Article
- Article
- Analogous effects of recombinant human full-length amelogenin expressed by Pichia pastoris yeast and enamel matrix derivative in vitro.Cell proliferation · 2012Article
- The role of cell surface markers and enamel matrix derivatives on human periodontal ligament mesenchymal progenitor responses in vitro.Biomaterials · 2011Article
- An amelogenin mutation leads to disruption of the odontogenic apparatus and aberrant expression of Notch1.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2011Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 4 countries.
Funding
Abstract
Regeneration of mineralized tissues affected by chronic diseases comprises a major scientific and clinical challenge. Periodontitis, one such prevalent disease, involves destruction of the tooth-supporting tissues, alveolar bone, periodontal-ligament and cementum, often leading to tooth loss. In 1997, it became clear that, in addition to their function in enamel formation, the hydrophobic ectodermal enamel matrix proteins (EMPs) play a role in the regeneration of these periodontal tissues. The epithelial EMPs are a heterogeneous mixture of polypeptides encoded by several genes. It was not clear, however, which of these many EMPs induces the regeneration and what mechanisms are involved. Here we show that a single recombinant human amelogenin protein (rHAM(+)), induced in vivo regeneration of all tooth-supporting tissues after creation of experimental periodontitis in a dog model. To further understand the regeneration process, amelogenin expression was detected in normal and regenerating cells of the alveolar bone (osteocytes, osteoblasts and osteoclasts), periodontal ligament, cementum and in bone marrow stromal cells. Amelogenin expression was highest in areas of high bone turnover and activity. Further studies showed that during the first 2 weeks after application, rHAM(+) induced, directly or indirectly, significant recruitment of mesenchymal progenitor cells, which later differentiated to form the regenerated periodontal tissues. The ability of a single protein to bring about regeneration of all periodontal tissues, in the correct spatio-temporal order, through recruitment of mesenchymal progenitor cells, could pave the way for development of new therapeutic devices for treatment of periodontal, bone and ligament diseases based on rHAM(+).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.